SPI1

SPI1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PUE
Dynodwyr
Cyfenwau	SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10
Dynodwyr allanol	OMIM: 165170 HomoloGene: 2346 GeneCards: SPI1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • RNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • NFAT protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • transcription regulator complex Prosesau biolegol • myeloid leukocyte differentiation • GO:0009373 regulation of transcription, DNA-templated • cellular response to ethanol • somatic stem cell population maintenance • lymphocyte differentiation • regulation of erythrocyte differentiation • myeloid dendritic cell differentiation • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of MHC class II biosynthetic process • lymphoid progenitor cell differentiation • transcription, DNA-templated • macrophage differentiation • anatomical structure regression • negative regulation of histone H4 acetylation • negative regulation of gene expression, epigenetic • vasculature development • granulocyte differentiation • apoptotic process involved in blood vessel morphogenesis • histone H3 acetylation • erythrocyte differentiation • hypermethylation of CpG island • positive regulation of pri-miRNA transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0045996 negative regulation of transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • pri-miRNA transcription by RNA polymerase II • cell differentiation • interleukin-6-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6688	n/a
Ensembl	ENSG00000066336	n/a
UniProt	P17947	n/a
RefSeq (mRNA)	NM_001080547 NM_003120	n/a
RefSeq (protein)	NP_001074016 NP_003111	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPI1 yw SPI1 a elwir hefyd yn Spi-1 proto-oncogene (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p11.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPI1.

• "Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells. ". Biochem Biophys Res Commun. 2016. PMID 26657848.
• "Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia. ". Leukemia. 2016. PMID 26126967.
• "Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia. ". Nat Genet. 2017. PMID 28671687.
• "Restoring PU.1 induces apoptosis and modulates viral transactivation via interferon-stimulated genes in primary effusion lymphoma. ". Oncogene. 2017. PMID 28481873.
• "PU.1 is involved in the immune response to Aspergillus fumigatus through upregulating Dectin-1 expression.". BMC Infect Dis. 2016. PMID 27306059.