SOX2

SOX2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1O4X, 2LE4
Dynodwyr
Cyfenwau	SOX2, ANOP3, MCOPS3, SRY-box 2, Sox2, SRY-box transcription factor 2
Dynodwyr allanol	OMIM: 184429 HomoloGene: 68298 GeneCards: SOX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • miRNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cytosol • transcription regulator complex • nucleoplasm • cnewyllyn cell Prosesau biolegol • eye development • pituitary gland development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of neuron differentiation • somatic stem cell population maintenance • endodermal cell fate specification • positive regulation of cell-cell adhesion • tissue regeneration • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • transcription by RNA polymerase II • regulation of cysteine-type endopeptidase activity involved in apoptotic process • adenohypophysis development • transcription, DNA-templated • neuronal stem cell population maintenance • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • multicellular organism development • glial cell fate commitment • response to wounding • osteoblast differentiation • positive regulation of cell differentiation • negative regulation of epithelial cell proliferation • regulation of gene expression • inner ear development • forebrain development • response to growth factor • negative regulation of canonical Wnt signaling pathway • positive regulation of MAPK cascade • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cytokine-mediated signaling pathway • cell differentiation • cell fate commitment • central nervous system development • neuron differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6657	n/a
Ensembl	ENSG00000181449	n/a
UniProt	P48431	n/a
RefSeq (mRNA)	NM_003106	n/a
RefSeq (protein)	NP_003097	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SOX2 yw SOX2 a elwir hefyd yn SRY-box 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q26.33.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SOX2.

• ANOP3
• MCOPS3

• "Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells. ". Mol Med Rep. 2017. PMID 28259951.
• "SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer. ". Am J Respir Crit Care Med. 2017. PMID 28199128.
• "Increased SOX2 expression in salivary gland carcinoma ex pleomorphic adenoma progression: an association with adverse outcome. ". Virchows Arch. 2017. PMID 28842747.
• "The influence of rAAV2-mediated SOX2 delivery into neonatal and adult human RPE cells; a comparative study. ". J Cell Physiol. 2018. PMID 28480968.
• "Actinomycin D Down-regulates SOX2 Expression and Induces Death in Breast Cancer Stem Cells.". Anticancer Res. 2017. PMID 28373426.