SMAD4

SMAD4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DD1, 1G88, 1MR1, 1U7F, 1U7V, 1YGS, 5MEY, 5MEZ, 5MF0
Dynodwyr
Cyfenwau	SMAD4, DPC4, JIP, MADH4, MYHRS, SMAD family member 4
Dynodwyr allanol	OMIM: 600993 HomoloGene: 31310 GeneCards: SMAD4
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • protein heterodimerization activity; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • metal ion binding; • DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • sequence-specific DNA binding; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • I-SMAD binding; • collagen binding; • GO:0001948, GO:0016582 protein binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • R-SMAD binding; • identical protein binding; • sulfate binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001104 transcription coregulator activity; • molecular function regulator; • chromatin binding;
Cydrannau o'r gell	• cnewyllyn cell; • cytoplasm; • transcription regulator complex; • activin responsive factor complex; • intracellular anatomical structure; • RNA polymerase II transcription regulator complex; • nucleoplasm; • centrosome; • cytosol; • SMAD protein complex;
Prosesau biolegol	• negative regulation of cell population proliferation; • spermatogenesis; • positive regulation of pathway-restricted SMAD protein phosphorylation; • positive regulation of luteinizing hormone secretion; • regulation of cell population proliferation; • cardiac septum development; • negative regulation of cell death; • regulation of hair follicle development; • cellular response to BMP stimulus; • epithelial to mesenchymal transition involved in endocardial cushion formation; • brainstem development; • cell population proliferation; • regulation of binding; • SMAD protein complex assembly; • metanephric mesenchyme morphogenesis; • positive regulation of epithelial to mesenchymal transition; • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • branching involved in ureteric bud morphogenesis; • GO:0009373 regulation of transcription, DNA-templated; • embryonic digit morphogenesis; • uterus development; • axon guidance; • somatic stem cell population maintenance; • gastrulation; • positive regulation of histone H3-K4 methylation; • GO:0045996 negative regulation of transcription, DNA-templated; • response to transforming growth factor beta; • endothelial cell activation; • positive regulation of transforming growth factor beta receptor signaling pathway; • single fertilization; • transforming growth factor beta receptor signaling pathway; • anterior/posterior pattern specification; • in utero embryonic development; • positive regulation of cell proliferation involved in heart valve morphogenesis; • atrioventricular valve formation; • GO:0007243 intracellular signal transduction; • developmental growth; • endoderm development; • cellular iron ion homeostasis; • kidney development; • GO:0007364, GO:0007361, GO:0007358 formation of anatomical boundary; • positive regulation of histone H3-K9 acetylation; • regulation of transforming growth factor beta2 production; • interleukin-6-mediated signaling pathway; • GO:1901227 negative regulation of transcription by RNA polymerase II; • male gonad development; • ovarian follicle development; • endocardial cell differentiation; • nephrogenic mesenchyme morphogenesis; • gastrulation with mouth forming second; • female gonad development; • SMAD protein signal transduction; • response to hypoxia; • atrioventricular canal development; • mesoderm development; • negative regulation of cell growth; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • BMP signaling pathway; • tissue morphogenesis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of SMAD protein signal transduction; • somite rostral/caudal axis specification; • sebaceous gland development; • positive regulation of follicle-stimulating hormone secretion; • positive regulation of BMP signaling pathway; • neural crest cell differentiation; • seminiferous tubule development; • female gonad morphogenesis; • regulation of transforming growth factor beta receptor signaling pathway; • neuron fate commitment; • transcription, DNA-templated; • outflow tract septum morphogenesis; • left ventricular cardiac muscle tissue morphogenesis; • negative regulation of cardiac muscle hypertrophy; • protein deubiquitination; • ventricular septum morphogenesis; • negative regulation of ERK1 and ERK2 cascade; • negative regulation of cardiac myofibril assembly; • protein homotrimerization; • pri-miRNA transcription by RNA polymerase II; • secondary palate development; • anatomical structure morphogenesis; • cell differentiation; • mesendoderm development;
	Sources:Amigo / QuickGO
Orthologau
	4089
	n/a
	ENSG00000141646
	n/a
	Q13485
	n/a
	NM_005359
	n/a
	NP_005350
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMAD4 yw SMAD4 a elwir hefyd yn SMAD family member 4 a Mothers against decapentaplegic homolog 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18q21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMAD4.

JIP
DPC4
MADH4
MYHRS

Llyfryddiaeth

"Functional characteristics of a novel SMAD4 mutation from thoracic aortic aneurysms (TAA). ". Gene. 2017. PMID 28716708.
"Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer. ". Oncotarget. 2017. PMID 28423626.
Myhre Syndrome. 1993. PMID 28406602.
"DPC4 gene expression in primary pancreatic ductal adenocarcinoma: relationship with CT characteristics. ". Br J Radiol. 2017. PMID 28339284.
"Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia.". Cancer Med. 2017. PMID 28256094.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SMAD4 - Cronfa NCBI

[1]

[2]

SMAD4

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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