SKI

SKI
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MR1, 1SBX
Dynodwyr
Cyfenwau	SKI, SKI proto-oncogene, SGS, SKV
Dynodwyr allanol	OMIM: 164780 HomoloGene: 31124 GeneCards: SKI
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001106 transcription corepressor activity; • protein domain specific binding; • histone deacetylase inhibitor activity; • zinc ion binding; • GO:0001948, GO:0016582 protein binding; • SMAD binding; • protein kinase binding; • ubiquitin protein ligase binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• PML body; • centrosome; • nuclear body; • cnewyllyn cell; • nucleoplasm; • transcription regulator complex; • cytoplasm; • transcription repressor complex; • GO:0009327 protein-containing complex;
Prosesau biolegol	• roof of mouth development; • myotube differentiation; • SMAD protein signal transduction; • somatic stem cell population maintenance; • nose morphogenesis; • cell motility; • bone morphogenesis; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of transforming growth factor beta receptor signaling pathway; • BMP signaling pathway; • negative regulation of osteoblast differentiation; • myelination in peripheral nervous system; • protein homotrimerization; • negative regulation of BMP signaling pathway; • positive regulation of Wnt signaling pathway; • negative regulation of activin receptor signaling pathway; • neural tube closure; • lens morphogenesis in camera-type eye; • embryonic limb morphogenesis; • skeletal muscle fiber development; • retina development in camera-type eye; • camera-type eye development; • positive regulation of DNA binding; • olfactory bulb development; • cell population proliferation; • anterior/posterior axis specification; • negative regulation of fibroblast proliferation; • face morphogenesis; • camera-type eye morphogenesis; • negative regulation of Schwann cell proliferation; • negative regulation of cell population proliferation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • negative regulation of histone deacetylation; • neuron development; • transforming growth factor beta receptor signaling pathway; • negative regulation of cell differentiation;
	Sources:Amigo / QuickGO
Orthologau
	6497
	n/a
	ENSG00000157933
	n/a
	P12755
	n/a
	NM_003036
	n/a
	NP_003027
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SKI yw SKI a elwir hefyd yn SKI proto-oncogene (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.33-p36.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SKI.

SGS
SKV

Llyfryddiaeth

"Ski regulates Smads and TAZ signaling to suppress lung cancer progression. ". Mol Carcinog. 2017. PMID 28398634.
"The SMAD-binding domain of SKI: a hotspot for de novo mutations causing Shprintzen-Goldberg syndrome. ". Eur J Hum Genet. 2015. PMID 24736733.
"c-Ski activates cancer-associated fibroblasts to regulate breast cancer cell invasion. ". Mol Oncol. 2013. PMID 24011664.
"576 kb deletion in 1p36.33-p36.32 containing SKI is associated with limb malformation, congenital heart disease and epilepsy. ". Gene. 2013. PMID 23892090.
"Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer.". Virology. 2013. PMID 23809940.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SKI - Cronfa NCBI

[1]

[2]

SKI

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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