SF3B1

2F9D, 2F9J, 2PEH, 3LQV, 4OZ1, 2FHO

SF3B1
SF3B1
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauSF3B1, Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155, splicing factor 3b subunit 1
Dynodwyr allanolOMIM: 605590 HomoloGene: 6696 GeneCards: SF3B1
Patrwm RNA pattern


Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez

23451

n/a

Ensembl

ENSG00000115524

n/a

UniProt

O75533

n/a

RefSeq (mRNA)

NM_001005526
NM_001308824
NM_012433

n/a

RefSeq (protein)

NP_001005526
NP_001295753
NP_036565

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SF3B1 yw SF3B1 a elwir hefyd yn Splicing factor 3b subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q33.1.[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SF3B1.

  • MDS
  • PRP10
  • Hsh155
  • PRPF10
  • SAP155
  • SF3b155

Llyfryddiaeth

  • "SF3B1 is a stress-sensitive splicing factor that regulates both HSF1 concentration and activity. ". PLoS One. 2017. PMID 28445500.
  • "Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia. ". Cancer Cell. 2016. PMID 27818134.
  • "SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells. ". Blood. 2017. PMID 28634182.
  • "Single-Nucleotide Polymorphism Leading to False Allelic Fraction by Droplet Digital PCR. ". Clin Chem. 2017. PMID 28615231.
  • "Splicing factor mutations in MDS RARS and MDS/MPN-RS-T.". Int J Hematol. 2017. PMID 28466384.

Cyfeiriadau

  1. ↑ "Human PubMed Reference:".
  2. ↑ SF3B1 - Cronfa NCBI

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