SERPINB2

SERPINB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2ARR, 1BY7, 1JRR, 2ARQ
Dynodwyr
Cyfenwau	SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2, serpin family B member 2
Dynodwyr allanol	OMIM: 173390 HomoloGene: 20571 GeneCards: SERPINB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • extracellular region • cellbilen • extracellular space • cytoplasm Prosesau biolegol • negative regulation of peptidase activity • wound healing • negative regulation of apoptotic process • fibrinolysis • negative regulation of endopeptidase activity • interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5055	n/a
Ensembl	ENSG00000197632	n/a
UniProt	P05120	n/a
RefSeq (mRNA)	NM_002575 NM_001143818	n/a
RefSeq (protein)	NP_001137290 NP_002566	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINB2 yw SERPINB2 a elwir hefyd yn Plasminogen activator inhibitor 2 a Serpin family B member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18q21.33-q22.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINB2.

• "SERPINB2 is regulated by dynamic interactions with pause-release proteins and enhancer RNAs. ". Mol Immunol. 2017. PMID 28578223.
• "Influences on plasminogen activator inhibitor-2 polymorphism-associated recurrent cardiovascular disease risk in patients with high HDL cholesterol and inflammation. ". Atherosclerosis. 2016. PMID 27174532.
• "Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population. ". Lipids Health Dis. 2015. PMID 26573152.
• "The sGC activator inhibits the proliferation and migration, promotes the apoptosis of human pulmonary arterial smooth muscle cells via the up regulation of plasminogen activator inhibitor-2. ". Exp Cell Res. 2015. PMID 25704756.
• "SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer.". Mol Carcinog. 2014. PMID 23661500.