S100A9

S100A9
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IRJ, 1XK4, 4GGF, 4XJK
Dynodwyr
Cyfenwau	S100A9, 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14, S100 calcium binding protein A9, S100-A9
Dynodwyr allanol	OMIM: 123886 HomoloGene: 2227 GeneCards: S100A9
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • microtubule binding • zinc ion binding • signal transducer activity • metal ion binding • Toll-like receptor 4 binding • antioxidant activity • GO:0001948, GO:0016582 protein binding • RAGE receptor binding • arachidonic acid binding Cydrannau o'r gell • bilen • cellbilen • extracellular exosome • Cytosgerbwd • cnewyllyn cell • GO:0005578 extracellular matrix • extracellular space • nucleoplasm • cytosol • cell junction • secretory granule lumen • cytoplasm • extracellular region • collagen-containing extracellular matrix Prosesau biolegol • peptidyl-cysteine S-trans-nitrosylation • positive regulation of inflammatory response • chemokine production • proses y system imiwnedd • cellular oxidant detoxification • cell-cell signaling • GO:0032617 cytokine production • leukocyte migration involved in inflammatory response • neutrophil chemotaxis • defense response to fungus • chemotaxis • sequestering of zinc ion • neutrophil aggregation • positive regulation of cell growth • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • regulation of inflammatory response • innate immune response • inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of intrinsic apoptotic signaling pathway • regulation of cytoskeleton organization • GO:0097285 apoptotic process • autophagy • toll-like receptor signaling pathway • antimicrobial humoral response • neutrophil degranulation • positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6280	n/a
Ensembl	ENSG00000163220	n/a
UniProt	P06702	n/a
RefSeq (mRNA)	NM_002965	n/a
RefSeq (protein)	NP_002956	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn S100A9 yw S100A9 a elwir hefyd yn S100 calcium binding protein A9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q21.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn S100A9.

• "Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. ". Arthritis Res Ther. 2017. PMID 28081709.
• "Regulatory mechanism and functional analysis of S100A9 in acute promyelocytic leukemia cells. ". Front Med. 2017. PMID 28063140.
• "S100A9 potentiates the activation of neutrophils by the etiological agent of gout, monosodium urate crystals. ". J Leukoc Biol. 2017. PMID 28550118.
• "Elevated calprotectin in patients with atrial fibrillation with and without heart failure. ". Scand J Clin Lab Invest. 2017. PMID 28276729.
• "A prospective single centre pilot evaluation of a serum calprotectin assay in unselected GI patients.". Clin Biochem. 2017. PMID 28093196.