RUVBL2

RUVBL2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CQA, 2XSZ, 3UK6
Dynodwyr
Cyfenwau	RUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46, ECP-51, TAP54-beta, RuvB like AAA ATPase 2
Dynodwyr allanol	OMIM: 604788 HomoloGene: 4856 GeneCards: RUVBL2
EC number	3.6.4.12
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • nucleotide binding • GO:0043141 5'-3' DNA helicase activity • GO:0008026 helicase activity • unfolded protein binding • GO:0004003 DNA helicase activity • ATPase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • chromatin DNA binding • ATP binding • hydrolase activity • RNA polymerase II core promoter sequence-specific DNA binding • TFIID-class transcription factor complex binding • protein homodimerization activity • ADP binding • ATPase binding Cydrannau o'r gell • bilen • nuclear matrix • NuA4 histone acetyltransferase complex • intracellular anatomical structure • nucleoplasm • MLL1 complex • extracellular exosome • cnewyllyn cell • Swr1 complex • R2TP complex • cytoplasm • centrosome • cytosol • Ino80 complex Prosesau biolegol • chromatin remodeling • DNA recombination • GO:0009373 regulation of transcription, DNA-templated • cellular response to UV • histone H2A acetylation • cellular response to estradiol stimulus • transcription, DNA-templated • positive regulation of histone acetylation • cellular response to DNA damage stimulus • establishment of protein localization to chromatin • protein folding • positive regulation of telomerase RNA localization to Cajal body • histone H4 acetylation • regulation of growth • GO:0100026 DNA repair • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • DNA duplex unwinding • box C/D snoRNP assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10856	n/a
Ensembl	ENSG00000183207	n/a
UniProt	Q9Y230	n/a
RefSeq (mRNA)	NM_006666 NM_001321190 NM_001321191	n/a
RefSeq (protein)	NP_001308119 NP_001308120 NP_006657	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RUVBL2 yw RUVBL2 a elwir hefyd yn RuvB like AAA ATPase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.33.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RUVBL2.

• "In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence. ". J Hepatol. 2010. PMID 20346530.
• "Reptin52 expression during in vitro neural differentiation of human embryonic stem cells. ". Neurosci Lett. 2009. PMID 19444951.
• "Reptin regulates insulin-stimulated Akt phosphorylation in hepatocellular carcinoma via the regulation of SHP-1/PTPN6. ". Cell Biochem Funct. 2017. PMID 28833338.
• "Reptin regulates DNA double strand breaks repair in human hepatocellular carcinoma. ". PLoS One. 2015. PMID 25875766.
• "Overexpression of reptin in renal cell carcinoma contributes to tumor malignancies and its inhibition triggers senescence of cancer cells.". Urol Oncol. 2013. PMID 22341977.