RUNX2

RUNX2
Dynodwyr
Cyfenwau	RUNX2, AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA, runt related transcription factor 2, Runx2 mRNA, RUNX family transcription factor 2
Dynodwyr allanol	OMIM: 600211 HomoloGene: 68389 GeneCards: RUNX2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • protein domain specific binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • chromatin binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • bHLH transcription factor binding; • GO:0001948, GO:0016582 protein binding; • ATP binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • transcription regulator complex; • cnewyllyn cell; • nucleoplasm; • cytosol;
Prosesau biolegol	• skeletal system development; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of smoothened signaling pathway; • chondrocyte differentiation; • ossification; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • regulation of fibroblast growth factor receptor signaling pathway; • skeletal system morphogenesis; • chondrocyte development; • cellular response to BMP stimulus; • endochondral ossification; • regulation of odontogenesis of dentin-containing tooth; • cell maturation; • BMP signaling pathway; • stem cell differentiation; • transcription, DNA-templated; • odontogenesis of dentin-containing tooth; • T cell differentiation; • GO:1901313 positive regulation of gene expression; • regulation of osteoblast differentiation; • positive regulation of chondrocyte differentiation; • osteoblast differentiation; • neuron differentiation; • positive regulation of cell population proliferation; • regulation of cell differentiation; • osteoblast development; • embryonic cranial skeleton morphogenesis; • regulation of ossification; • embryonic forelimb morphogenesis; • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; • osteoblast fate commitment; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • transcription initiation from RNA polymerase II promoter; • positive regulation of osteoblast differentiation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cell differentiation; • hemopoiesis; • regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologau
	860
	n/a
	ENSG00000124813
	n/a
	Q13950
	n/a
	NM_001015051; NM_001024630; NM_001278478; NM_004348; NM_001369405
	n/a
	NP_001015051; NP_001019801; NP_001265407; NP_001356334
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RUNX2 yw RUNX2 a elwir hefyd yn Runt related transcription factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RUNX2.

CCD
AML3
CCD1
CLCD
OSF2
CBFA1
OSF-2
PEA2aA
PEBP2aA
CBF-alpha-1

Llyfryddiaeth

"Analysis of novel RUNX2 mutations in Chinese patients with cleidocranial dysplasia. ". PLoS One. 2017. PMID 28738062.
"A novel RUNX2 mutation in exon 8, G462X, in a patient with Cleidocranial Dysplasia. ". J Cell Biochem. 2018. PMID 28703881.
"Functional analysis of novel RUNX2 mutations in cleidocranial dysplasia. ". Mutagenesis. 2017. PMID 28505335.
"Wnt/β-Catenin Signaling Activates Expression of the Bone-Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types. ". J Cell Biochem. 2017. PMID 28370561.
"The role of Runx2 in facilitating autophagy in metastatic breast cancer cells.". J Cell Physiol. 2018. PMID 28345763.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RUNX2 - Cronfa NCBI

[1]

[2]

RUNX2

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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