RUNX1

RUNX1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1CMO, 1CO1, 1E50, 1H9D, 1LJM
Dynodwyr
Cyfenwau	RUNX1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, runt related transcription factor 1, RUNX family transcription factor 1
Dynodwyr allanol	OMIM: 151385 HomoloGene: 1331 GeneCards: RUNX1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • calcium ion binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • protein homodimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • GO:0001948, GO:0016582 protein binding; • protein heterodimerization activity; • ATP binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cydrannau o'r gell	• intracellular membrane-bounded organelle; • cnewyllyn cell; • cytosol; • nucleoplasm; • core-binding factor complex;
Prosesau biolegol	• peripheral nervous system neuron development; • myeloid cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • chondrocyte differentiation; • ossification; • negative regulation of granulocyte differentiation; • hematopoietic stem cell proliferation; • transcription, DNA-templated; • positive regulation of angiogenesis; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of interleukin-2 production; • positive regulation of granulocyte differentiation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • regulation of cytokine-mediated signaling pathway; • regulation of Wnt signaling pathway; • regulation of intracellular estrogen receptor signaling pathway; • regulation of regulatory T cell differentiation; • regulation of keratinocyte differentiation; • regulation of myeloid cell differentiation; • regulation of megakaryocyte differentiation; • regulation of B cell receptor signaling pathway; • regulation of hematopoietic stem cell differentiation; • regulation of bicellular tight junction assembly; • hemopoiesis; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of CD4-positive, alpha-beta T cell differentiation; • positive regulation of CD8-positive, alpha-beta T cell differentiation; • negative regulation of gene expression; • neuron differentiation;
	Sources:Amigo / QuickGO
Orthologau
	861
	n/a
	ENSG00000159216
	n/a
	Q01196
	n/a
	NM_001001890; NM_001122607; NM_001754
	n/a
	NP_001001890; NP_001116079; NP_001745
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RUNX1 yw RUNX1 a elwir hefyd yn Runt related transcription factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 21, band 21q22.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RUNX1.

AML1
CBFA2
EVI-1
AMLCR1
PEBP2aB
CBF2alpha
AML1-EVI-1
PEBP2alpha

Llyfryddiaeth

"RUNX1 Upregulation by Cytotoxic Drugs Promotes Apoptosis. ". Cancer Res. 2017. PMID 29055018.
"Frequency and Clinicopathologic Features of RUNX1 Mutations in Patients With Acute Myeloid Leukemia Not Otherwise Specified. ". Am J Clin Pathol. 2017. PMID 28927163.
"H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1alterations. ". Blood. 2017. PMID 28855157.
"Myeloid neoplasms with germ line RUNX1 mutation. ". Int J Hematol. 2017. PMID 28534116.
"Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree.". Eur J Hum Genet. 2017. PMID 28513614.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RUNX1 - Cronfa NCBI

[1]

[2]

RUNX1

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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