RNF25

RNF25
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DAY, 2DMF, 5D1M, 5D1L, 5D1K
Dynodwyr
Cyfenwau	RNF25, AO7, ring finger protein 25
Dynodwyr allanol	OMIM: 616014 HomoloGene: 11193 GeneCards: RNF25
EC number	2.3.2.27
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • NF-kappaB binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytosol • cnewyllyn cell Prosesau biolegol • positive regulation of NF-kappaB transcription factor activity • protein ubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	64320	n/a
Ensembl	ENSG00000163481	n/a
UniProt	Q96BH1	n/a
RefSeq (mRNA)	NM_022453	n/a
RefSeq (protein)	NP_071898	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RNF25 yw RNF25 a elwir hefyd yn Ring finger protein 25 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q35.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RNF25.

• AO7

• "EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. ". Proc Natl Acad Sci U S A. 2008. PMID 18757723.
• "A conserved catalytic residue in the ubiquitin-conjugating enzyme family. ". EMBO J. 2003. PMID 14517261.
• "Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. ". J Biol Chem. 2015. PMID 26475854.
• "The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin. ". Biochemistry. 2014. PMID 24901938.
• "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit.". J Biol Chem. 2003. PMID 12748188.