RFC1

RFC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EBU, 2K6G, 2K7F
Dynodwyr
Cyfenwau	RFC1, RFC, replication factor C subunit 1, A1, PO-GA, RECC1, MHCBFB, RFC140, CANVAS
Dynodwyr allanol	OMIM: 102579 HomoloGene: 2187 GeneCards: RFC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0001948, GO:0016582 protein binding • GO:0010577 enzyme activator activity • ATP binding • DNA clamp loader activity • DNA binding • sequence-specific DNA binding • double-stranded DNA binding • protein domain specific binding • DNA clamp unloader activity Cydrannau o'r gell • nucleoplasm • extracellular exosome • DNA replication factor C complex • cnewyllyn cell • nucleolus • cytoplasm • Elg1 RFC-like complex • GO:0009327 protein-containing complex Prosesau biolegol • DNA-dependent DNA replication • nucleotide-excision repair, DNA gap filling • GO:0009373 regulation of transcription, DNA-templated • telomere maintenance via telomerase • error-free translesion synthesis • transcription, DNA-templated • error-prone translesion synthesis • DNA replication • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • GO:0100026 DNA repair • nucleotide-excision repair, DNA incision, 5'-to lesion • GO:0048554 positive regulation of catalytic activity • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0045996 negative regulation of transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • telomere maintenance via semi-conservative replication • DNA clamp unloading Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5981	n/a
Ensembl	ENSG00000035928	n/a
UniProt	P35251	n/a
RefSeq (mRNA)	NM_001204747 NM_002913 NM_001363495 NM_001363496	n/a
RefSeq (protein)	NP_001191676 NP_002904 NP_001350424 NP_001350425	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RFC1 yw RFC1 a elwir hefyd yn Replication factor C subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4p14.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RFC1.

• "RFC1 and non-syndromic cleft lip with or without cleft palate: an association based study in Italy. ". J Craniomaxillofac Surg. 2014. PMID 24942095.
• "The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis. ". Nutrients. 2013. PMID 23857226.
• "The association between reduced folate carrier-1 gene 80G/A polymorphism and methotrexate efficacy or methotrexate related-toxicity in rheumatoid arthritis: A meta-analysis. ". Int Immunopharmacol. 2016. PMID 27233001.
• "Reduced folate carrier-1 80G > A gene polymorphism is not associated with methotrexate treatment response in South Indian Tamils with rheumatoid arthritis. ". Clin Rheumatol. 2016. PMID 25771854.
• "Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence.". Proc Natl Acad Sci U S A. 2014. PMID 25071216.