RELA

RELA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N22
Dynodwyr
Cyfenwau	RELA, NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU
Dynodwyr allanol	OMIM: 164014 HomoloGene: 32064 GeneCards: RELA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein N-terminus binding • ankyrin repeat binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • histone deacetylase binding • enzyme binding • phosphate ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • protein homodimerization activity • chromatin binding • NF-kappaB binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • DNA binding • sequence-specific DNA binding • actinin binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chromatin DNA binding • ubiquitin protein ligase binding • GO:0000983 RNA polymerase II general transcription initiation factor activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • cytosol • I-kappaB/NF-kappaB complex • transcription regulator complex • NF-kappaB complex • nucleoplasm • cnewyllyn cell • nucleolus • NF-kappaB p50/p65 complex • GO:0009327 protein-containing complex • synapse • glutamatergic synapse Prosesau biolegol • response to amino acid • response to interleukin-1 • cellular response to interleukin-6 • response to progesterone • response to organic substance • Fc-epsilon receptor signaling pathway • GO:1903105 negative regulation of insulin receptor signaling pathway • defense response to virus • positive regulation of chondrocyte differentiation • animal organ morphogenesis • response to muscle stretch • response to cytokine • GO:1903363 negative regulation of protein catabolic process • cytokine-mediated signaling pathway • negative regulation of extrinsic apoptotic signaling pathway • response to mechanical stimulus • response to muramyl dipeptide • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • response to insulin • negative regulation of NIK/NF-kappaB signaling • nucleotide-binding oligomerization domain containing 2 signaling pathway • membrane protein intracellular domain proteolysis • inflammatory response • GO:0022415 viral process • response to cobalamin • hair follicle development • positive regulation of miRNA metabolic process • acetaldehyde metabolic process • cellular response to hepatocyte growth factor stimulus • cellular response to nicotine • negative regulation of apoptotic process • cellular defense response • response to morphine • response to lipopolysaccharide • cellular response to interleukin-1 • ymateb i sylwedd anorganig • regulation of inflammatory response • response to cAMP • GO:0045996 negative regulation of transcription, DNA-templated • response to hydrogen peroxide • positive regulation of Schwann cell differentiation • defense response • response to bacterium • GO:1904578 response to organic cyclic compound • GO:0010260 heneiddio • positive regulation of cell population proliferation • positive regulation of I-kappaB kinase/NF-kappaB signaling • liver development • response to UV-B • T cell receptor signaling pathway • cellular response to lipopolysaccharide • positive regulation of type I interferon production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to hydrogen peroxide • GO:0009373 regulation of transcription, DNA-templated • tumor necrosis factor-mediated signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of T cell receptor signaling pathway • positive regulation of NF-kappaB transcription factor activity • cellular response to peptidoglycan • cellular response to tumor necrosis factor • regulation of NIK/NF-kappaB signaling • positive regulation of NIK/NF-kappaB signaling • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • positive regulation of pri-miRNA transcription by RNA polymerase II • regulation of DNA-templated transcription in response to stress • cellular response to lipoteichoic acid • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of protein sumoylation • pri-miRNA transcription by RNA polymerase II • cellular response to angiotensin • interleukin-1-mediated signaling pathway • cellular response to vascular endothelial growth factor stimulus • negative regulation of pri-miRNA transcription by RNA polymerase II • postsynapse to nucleus signaling pathway • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • I-kappaB kinase/NF-kappaB signaling • NIK/NF-kappaB signaling • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5970	n/a
Ensembl	ENSG00000173039	n/a
UniProt	Q04206	n/a
RefSeq (mRNA)	NM_001145138 NM_001243984 NM_001243985 NM_021975	n/a
RefSeq (protein)	NP_001138610 NP_001230913 NP_001230914 NP_068810	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RELA yw RELA a elwir hefyd yn Transcription factor p65 a RELA proto-oncogene, NF-kB subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RELA.

• p65
• NFKB3

• "NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells. ". Cancer Res. 2017. PMID 29074539.
• "Human RELAhaploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. ". J Exp Med. 2017. PMID 28600438.
• "Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, suppresses the growth and invasion of human oral squamous cell carcinoma cells via the NF-κB pathway. ". J Biochem Mol Toxicol. 2017. PMID 28548219.
• "RelA/p65 inhibition prevents tendon adhesion by modulating inflammation, cell proliferation, and apoptosis. ". Cell Death Dis. 2017. PMID 28358376.
• "Formula PSORI-CM01 inhibits the inflammatory cytokine and chemokine release in keratinocytes via NF-κB expression.". Int Immunopharmacol. 2017. PMID 28129604.