RBPJ

RBPJ
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2F8X, 3NBN, 3V79
Dynodwyr
Cyfenwau	RBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1
Dynodwyr allanol	OMIM: 147183 HomoloGene: 7511 GeneCards: RBPJ
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein N-terminus binding • GO:0001948, GO:0016582 protein binding • DNA strand exchange activity • chromatin binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleolus • MAML1-RBP-Jkappa- ICN1 complex • transcription regulator complex • cytoplasm • cnewyllyn cell • nucleoplasm • transcription repressor complex Prosesau biolegol • artery morphogenesis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • neuron differentiation • epidermal cell fate specification • positive regulation of cell population proliferation • club cell differentiation • somatic stem cell population maintenance • endocardium development • cell fate commitment • DNA recombination • somitogenesis • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • defense response to bacterium • regulation of timing of cell differentiation • GO:0009373 regulation of transcription, DNA-templated • humoral immune response • keratinocyte differentiation • hair follicle maturation • negative regulation of cell population proliferation • pituitary gland development • negative regulation of cell differentiation • Notch signaling involved in heart development • transcription, DNA-templated • GO:1901313 positive regulation of gene expression • arterial endothelial cell fate commitment • myeloid dendritic cell differentiation • blood vessel remodeling • secondary heart field specification • regulation of cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription initiation from RNA polymerase II promoter • sebaceous gland development • positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment • inflammatory response to antigenic stimulus • development of the heart • auditory receptor cell fate commitment • B cell differentiation • regulation of gene expression • Notch signaling pathway • dorsal aorta morphogenesis • atrioventricular canal development • positive regulation of ephrin receptor signaling pathway • epithelial to mesenchymal transition involved in endocardial cushion formation • outflow tract morphogenesis • cardiac left ventricle morphogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • labyrinthine layer blood vessel development • blood vessel lumenization • endocardium morphogenesis • ventricular trabecula myocardium morphogenesis • negative regulation of ossification • positive regulation of cell proliferation involved in heart morphogenesis • positive regulation of cardiac muscle cell proliferation • angiogenesis • epithelial to mesenchymal transition • positive regulation of BMP signaling pathway • positive regulation of ERBB signaling pathway • blood vessel endothelial cell fate specification • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of transcription of Notch receptor target • positive regulation of Notch signaling pathway • hemopoiesis • aortic valve development • pulmonary valve development • ventricular septum morphogenesis • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3516	n/a
Ensembl	ENSG00000168214	n/a
UniProt	Q06330	n/a
RefSeq (mRNA)	NM_005349 NM_015874 NM_203283 NM_203284 NM_001363577 NM_001374400 NM_001374401 NM_001374402 NM_001374403 NM_001379406 NM_001379407 NM_001379408 NM_001379409	n/a
RefSeq (protein)	NP_005340 NP_056958 NP_976028 NP_976029 NP_001350506 NP_001361329 NP_001361330 NP_001361331 NP_001361332 NP_001366335 NP_001366336 NP_001366337 NP_001366338	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RBPJ yw RBPJ a elwir hefyd yn Recombination signal binding protein for immunoglobulin kappa J region a Recombining-binding protein suppressor of hairless (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p15.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RBPJ.

• "CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells. ". Br J Cancer. 2017. PMID 28571041.
• "Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells. ". Hum Mol Genet. 2016. PMID 26604133.
• "Inhibition of Recombining Binding Protein Suppressor of Hairless (RBPJ) Impairs the Growth of Prostate Cancer. ". Cell Physiol Biochem. 2015. PMID 26202358.
• "RBPJ inhibition impairs the growth of lung cancer. ". Tumour Biol. 2015. PMID 25589461.
• "Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines.". PLoS Pathog. 2013. PMID 23696732.