PSME1

PSME1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AVO
Dynodwyr
Cyfenwau	PSME1, IFI5111, PA28A, PA28alpha, REGalpha, HEL-S-129m, proteasome activator subunit 1
Dynodwyr allanol	OMIM: 600654 HomoloGene: 4560 GeneCards: PSME1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • endopeptidase activator activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • proteasome complex • cytoplasm • nucleoplasm • proteasome activator complex • cytosol • extracellular exosome Prosesau biolegol • tumor necrosis factor-mediated signaling pathway • protein polyubiquitination • T cell receptor signaling pathway • positive regulation of canonical Wnt signaling pathway • anaphase-promoting complex-dependent catabolic process • regulation of proteasomal protein catabolic process • regulation of G1/S transition of mitotic cell cycle • regulation of mRNA stability • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • antigen processing and presentation of exogenous antigen • regulation of cellular amino acid metabolic process • NIK/NF-kappaB signaling • Fc-epsilon receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • MAPK cascade • stimulatory C-type lectin receptor signaling pathway • positive regulation of endopeptidase activity • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway, planar cell polarity pathway • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5720	n/a
Ensembl	ENSG00000092010 ENSG00000284916	n/a
UniProt	Q06323	n/a
RefSeq (mRNA)	NM_176783 NM_001281528 NM_001281529 NM_006263	n/a
RefSeq (protein)	NP_001268457 NP_001268458 NP_006254 NP_788955	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSME1 yw PSME1 a elwir hefyd yn Proteasome activator subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q12.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSME1.

• "Proteasomes in immune cells: more than peptide producers?". Nat Rev Immunol. 2010. PMID 20010787.
• "Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells. ". Leukemia. 2009. PMID 19225532.
• "Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma. ". J Exp Clin Cancer Res. 2016. PMID 26892607.
• "Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies. ". Proc Natl Acad Sci U S A. 2013. PMID 23918357.
• "The C-terminal fragment of the immunoproteasome PA28S (Reg alpha) as an early diagnosis and tumor-relapse biomarker: evidence from mass spectrometry profiling.". Histochem Cell Biol. 2012. PMID 22532226.