PSMD10

PSMD10
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1QYM, 1TR4, 1UOH, 4NIK
Dynodwyr
Cyfenwau	PSMD10, dJ889N15.2, p28, p28(GANK), proteasome 26S subunit, non-ATPase 10
Dynodwyr allanol	OMIM: 300880 HomoloGene: 94517 GeneCards: PSMD10
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transcription factor binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• intermediate filament cytoskeleton; • cytoplasm; • nucleoplasm; • proteasome regulatory particle, base subcomplex; • cnewyllyn cell; • proteasome regulatory particle; • proteasome complex; • cytosol;
Prosesau biolegol	• negative regulation of release of cytochrome c from mitochondria; • cytoplasmic sequestering of NF-kappaB; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • positive regulation of cell growth; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of MAPK cascade; • negative regulation of DNA damage response, signal transduction by p53 class mediator; • proteasome regulatory particle assembly; • positive regulation of protein ubiquitination; • negative regulation of NF-kappaB transcription factor activity; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • negative regulation of apoptotic process; • GO:0097285 apoptotic process; • protein deubiquitination; • post-translational protein modification; • MAPK cascade; • protein polyubiquitination; • stimulatory C-type lectin receptor signaling pathway; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • regulation of cellular amino acid metabolic process; • negative regulation of G2/M transition of mitotic cell cycle; • anaphase-promoting complex-dependent catabolic process; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • tumor necrosis factor-mediated signaling pathway; • NIK/NF-kappaB signaling; • Fc-epsilon receptor signaling pathway; • proteasome-mediated ubiquitin-dependent protein catabolic process; • regulation of mRNA stability; • T cell receptor signaling pathway; • transmembrane transport; • Wnt signaling pathway, planar cell polarity pathway; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • interleukin-1-mediated signaling pathway; • negative regulation of canonical Wnt signaling pathway; • positive regulation of canonical Wnt signaling pathway; • regulation of mitotic cell cycle phase transition; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologau
	5716
	n/a
	ENSG00000101843
	n/a
	O75832
	n/a
	NM_170750; NM_002814
	n/a
	NP_002805; NP_736606
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMD10 yw PSMD10 a elwir hefyd yn Proteasome 26S subunit, non-ATPase 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMD10.

p28
p28(GANK)
dJ889N15.2

Llyfryddiaeth

"Gankyrin regulates cell signaling network. ". Tumour Biol. 2016. PMID 26819208.
"Clinicopathologic features and prognostic implications of Gankyrin protein expression in non-small cell lung cancer. ". Pathol Res Pract. 2015. PMID 26554593.
"Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. ". Mol Cell. 2017. PMID 28689658.
"Gankyrin promotes the proliferation of gastric cancer and is associated with chemosensitivity. ". Tumour Biol. 2017. PMID 28653901.
"Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.". Sci Rep. 2016. PMID 27046077.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PSMD10 - Cronfa NCBI

[1]

[2]

PSMD10

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

Content Disclaimer