PSMB4

PSMB4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4R3O, 4R67, 5A0Q
Dynodwyr
Cyfenwau	PSMB4, HN3, HsN3, PROS-26, PROS26, proteasome subunit beta 4, PRAAS3, proteasome 20S subunit beta 4
Dynodwyr allanol	OMIM: 602177 HomoloGene: 2090 GeneCards: PSMB4
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• endopeptidase activity; • lipopolysaccharide binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • threonine-type endopeptidase activity; • hydrolase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • nucleoplasm; • proteasome complex; • extracellular exosome; • cnewyllyn cell; • proteasome core complex; • proteasome core complex, beta-subunit complex;
Prosesau biolegol	• regulation of cellular amino acid metabolic process; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • regulation of mRNA stability; • positive regulation of canonical Wnt signaling pathway; • protein polyubiquitination; • stimulatory C-type lectin receptor signaling pathway; • tumor necrosis factor-mediated signaling pathway; • MAPK cascade; • proteolysis; • Fc-epsilon receptor signaling pathway; • NIK/NF-kappaB signaling; • negative regulation of inflammatory response to antigenic stimulus; • anaphase-promoting complex-dependent catabolic process; • proteolysis involved in cellular protein catabolic process; • T cell receptor signaling pathway; • negative regulation of canonical Wnt signaling pathway; • proteasome-mediated ubiquitin-dependent protein catabolic process; • GO:0022415 viral process; • Wnt signaling pathway, planar cell polarity pathway; • negative regulation of G2/M transition of mitotic cell cycle; • protein deubiquitination; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • transmembrane transport; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • post-translational protein modification; • regulation of hematopoietic stem cell differentiation; • proteasomal protein catabolic process; • proteasomal ubiquitin-independent protein catabolic process; • interleukin-1-mediated signaling pathway; • regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologau
	5692
	n/a
	ENSG00000159377
	n/a
	P28070
	n/a
	NM_002796
	n/a
	NP_002787
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMB4 yw PSMB4 a elwir hefyd yn Proteasome subunit beta 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMB4.

HN3
HsN3
PROS26
PROS-26

Llyfryddiaeth

"HsN3 proteasomal subunit as a target for human immunodeficiency virus type 1 Nef protein. ". Virology. 1997. PMID 9344905.
"PSMB4 expression associates with epithelial ovarian cancer growth and poor prognosis. ". Arch Gynecol Obstet. 2016. PMID 26439929.
"Cloning and expression of a human pro(tea)some beta-subunit cDNA: a homologue of the yeast PRE4-subunit essential for peptidylglutamyl-peptide hydrolase activity. ". FEBS Lett. 1994. PMID 8013624.
"Proteasome beta-4 subunit contributes to the development of melanoma and is regulated by miR-148b. ". Tumour Biol. 2017. PMID 28656878.
"Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies.". FEBS Lett. 2014. PMID 24291262.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PSMB4 - Cronfa NCBI

[1]

[2]

PSMB4

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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