PSMB3

PSMB3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4R3O, 4R67, 5A0Q
Dynodwyr
Cyfenwau	PSMB3, HC10-II, proteasome subunit beta 3, proteasome 20S subunit beta 3
Dynodwyr allanol	OMIM: 602176 HomoloGene: 2089 GeneCards: PSMB3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • endopeptidase activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • threonine-type endopeptidase activity • hydrolase activity Cydrannau o'r gell • cytosol • proteasome complex • extracellular exosome • cnewyllyn cell • proteasome core complex • nucleoplasm • cytoplasm • proteasome core complex, beta-subunit complex Prosesau biolegol • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of mRNA stability • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • proteolysis • MAPK cascade • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • anaphase-promoting complex-dependent catabolic process • proteolysis involved in cellular protein catabolic process • T cell receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • GO:0022415 viral process • Wnt signaling pathway, planar cell polarity pathway • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation • proteasomal protein catabolic process • proteasomal ubiquitin-independent protein catabolic process • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5691	n/a
Ensembl	n/a	n/a
UniProt	P49720	n/a
RefSeq (mRNA)	NM_002795	n/a
RefSeq (protein)	NP_002786	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMB3 yw PSMB3 a elwir hefyd yn Proteasome subunit beta 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q12.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMB3.

• HC10-II

• "RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5. ". Blood. 2011. PMID 21289309.
• "Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation. ". Int J Biochem Cell Biol. 2010. PMID 20080206.
• "The expression of inflammatory genes is upregulated in peripheral blood of patients with type 1 diabetes. ". Diabetes Care. 2013. PMID 23637351.
• "AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis. ". PLoS Pathog. 2011. PMID 21625534.
• "Gene expression profiling detects gene amplification and differentiates tumor types in breast cancer.". Cancer Res. 2003. PMID 12727839.