PSMB2

PSMB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4R3O, 4R67, 1IRU, 5A0Q
Dynodwyr
Cyfenwau	PSMB2, HC7-I, proteasome subunit beta 2, proteasome 20S subunit beta 2
Dynodwyr allanol	OMIM: 602175 HomoloGene: 2088 GeneCards: PSMB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • endopeptidase activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • threonine-type endopeptidase activity • hydrolase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • nucleoplasm • proteasome complex • extracellular exosome • cnewyllyn cell • proteasome core complex • proteasome core complex, beta-subunit complex Prosesau biolegol • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • GO:1904578 response to organic cyclic compound • regulation of mRNA stability • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • proteolysis • MAPK cascade • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • response to organonitrogen compound • anaphase-promoting complex-dependent catabolic process • proteolysis involved in cellular protein catabolic process • T cell receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway, planar cell polarity pathway • GO:0022415 viral process • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation • proteasomal protein catabolic process • proteasomal ubiquitin-independent protein catabolic process • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5690	n/a
Ensembl	ENSG00000126067	n/a
UniProt	P49721	n/a
RefSeq (mRNA)	NM_002794 NM_001199779 NM_001199780	n/a
RefSeq (protein)	NP_001186708 NP_001186709 NP_002785	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMB2 yw PSMB2 a elwir hefyd yn Proteasome subunit beta 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p34.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMB2.

• HC7-I

• "The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1. ". PLoS One. 2013. PMID 24244684.
• "Crystal structure of the human 20S proteasome in complex with carfilzomib. ". Structure. 2015. PMID 25599644.
• "The over-expression of the β2 catalytic subunit of the proteasome decreases homologous recombination and impairs DNA double-strand break repair in human cells. ". J Biomed Biotechnol. 2011. PMID 21660142.
• "Beta 2 subunit propeptides influence cooperative proteasome assembly. ". J Biol Chem. 2003. PMID 12456675.
• "Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues.". Biochim Biophys Acta. 1994. PMID 7918633.