PSMA3

PSMA3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4R3O, 4R67, 5DSV, 5A0Q
Dynodwyr
Cyfenwau	PSMA3, HC8, PSC3, proteasome subunit alpha 3, proteasome 20S subunit alpha 3
Dynodwyr allanol	OMIM: 176843 HomoloGene: 2082 GeneCards: PSMA3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • endopeptidase activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • threonine-type endopeptidase activity • hydrolase activity • ubiquitin protein ligase binding Cydrannau o'r gell • cytoplasm • cytosol • nucleoplasm • proteasome complex • extracellular exosome • cnewyllyn cell • proteasome core complex • synapse • proteasome core complex, alpha-subunit complex Prosesau biolegol • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of mRNA stability • ubiquitin-dependent protein catabolic process • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • proteolysis • MAPK cascade • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • anaphase-promoting complex-dependent catabolic process • proteolysis involved in cellular protein catabolic process • T cell receptor signaling pathway • negative regulation of canonical Wnt signaling pathway • regulation of endopeptidase activity • GO:0022415 viral process • Wnt signaling pathway, planar cell polarity pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation • proteasomal protein catabolic process • proteasomal ubiquitin-independent protein catabolic process • interleukin-1-mediated signaling pathway • regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5684	n/a
Ensembl	ENSG00000100567	n/a
UniProt	P25788	n/a
RefSeq (mRNA)	NM_002788 NM_152132	n/a
RefSeq (protein)	NP_002779 NP_687033	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMA3 yw PSMA3 a elwir hefyd yn Proteasome subunit alpha 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMA3.

• HC8
• PSC3

• "Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner. ". Mol Cell Biochem. 2003. PMID 14674694.
• "Regulation of Egr-1 by association with the proteasome component C8. ". Biochim Biophys Acta. 2002. PMID 12379479.
• "The value of correlation of serum 20S proteasome concentration and percentage of lymphocytic apoptosis in critically ill patients: a prospective observational study. ". Crit Care. 2010. PMID 21108816.
• "Ubiquitin-independent degradation of hepatitis C virus F protein. ". J Virol. 2009. PMID 18971267.
• "Uncoupling proteasome peptidase and ATPase activities results in cytosolic release of an ER polytopic protein.". J Cell Sci. 2006. PMID 16390870.