PSMA1

PSMA1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4R3O, 4R67, 1IRU, 5A0Q
Dynodwyr
Cyfenwau	PSMA1, HC2, HEL-S-275, NU, PROS30, Proteasome (prosome, macropain) subunit, alpha 1, proteasome subunit alpha 1, proteasome 20S subunit alpha 1
Dynodwyr allanol	OMIM: 602854 HomoloGene: 2080 GeneCards: PSMA1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• endopeptidase activity; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • RNA binding; • threonine-type endopeptidase activity; • hydrolase activity; • lipopolysaccharide binding;
Cydrannau o'r gell	• cytoplasm; • polysome; • cytosol; • centrosome; • nucleoplasm; • proteasome complex; • extracellular exosome; • cnewyllyn cell; • proteasome core complex; • proteasome core complex, alpha-subunit complex;
Prosesau biolegol	• regulation of cellular amino acid metabolic process; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • ubiquitin-dependent protein catabolic process; • regulation of mRNA stability; • proses y system imiwnedd; • positive regulation of canonical Wnt signaling pathway; • protein polyubiquitination; • stimulatory C-type lectin receptor signaling pathway; • tumor necrosis factor-mediated signaling pathway; • proteolysis; • MAPK cascade; • Fc-epsilon receptor signaling pathway; • NIK/NF-kappaB signaling; • anaphase-promoting complex-dependent catabolic process; • proteolysis involved in cellular protein catabolic process; • T cell receptor signaling pathway; • negative regulation of canonical Wnt signaling pathway; • proteasome-mediated ubiquitin-dependent protein catabolic process; • Wnt signaling pathway, planar cell polarity pathway; • negative regulation of G2/M transition of mitotic cell cycle; • protein deubiquitination; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • transmembrane transport; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • post-translational protein modification; • regulation of hematopoietic stem cell differentiation; • negative regulation of inflammatory response to antigenic stimulus; • proteasomal protein catabolic process; • proteasomal ubiquitin-independent protein catabolic process; • interleukin-1-mediated signaling pathway; • regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologau
	5682
	n/a
	ENSG00000129084
	n/a
	P25786
	n/a
	NM_148976; NM_001143937; NM_002786
	n/a
	NP_001137409; NP_002777; NP_683877
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMA1 yw PSMA1 a elwir hefyd yn Proteasome subunit alpha 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMA1.

NU
HC2
PROS30
HEL-S-275

Llyfryddiaeth

"Regulation of gene expression of proteasomes (multi-protease complexes) during growth and differentiation of human hematopoietic cells. ". J Biol Chem. 1992. PMID 1517242.
"Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes. ". Gene. 1992. PMID 1398136.
"Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. ". PLoS One. 2013. PMID 24040035.
"Sperm-specific C-terminal processing of the proteasome PSMA1/α6 subunit. ". Biochem Biophys Res Commun. 2011. PMID 21703233.
"Identical subunit topographies of human and yeast 20S proteasomes.". Arch Biochem Biophys. 1999. PMID 10068451.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PSMA1 - Cronfa NCBI

[1]

[2]

PSMA1

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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