PRSS1

1FXY, 1TRN, 2RA3, 4WWY, 4WXV

PRSS1
PRSS1
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauPRSS1, TRP1, TRY1, TRY4, TRYP1, Trypsin 1, protease, serine 1, serine protease 1
Dynodwyr allanolOMIM: 276000 HomoloGene: 134623 GeneCards: PRSS1
EC number3.4.21.4
Patrwm RNA pattern
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez

5644

n/a

Ensembl

ENSG00000274247
ENSG00000204983

n/a

UniProt

P07477

n/a

RefSeq (mRNA)

NM_002769

n/a

RefSeq (protein)

NP_002760

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRSS1 yw PRSS1 a elwir hefyd yn Protease, serine 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q34.[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRSS1.

  • TRP1
  • TRY1
  • TRY4
  • TRYP1

Llyfryddiaeth

  • "Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids. ". PLoS One. 2014. PMID 25010489.
  • "Human cationic trypsinogen but not serine peptidase inhibitor, Kazal type 1 variants increase the risk of type 1 autoimmune pancreatitis. ". J Gastroenterol Hepatol. 2014. PMID 24909264.
  • "Discovery and Functional Annotation of PRSS1 Promoter Variants in Chronic Pancreatitis. ". Hum Mutat. 2016. PMID 27432637.
  • "Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis. ". Am J Physiol Gastrointest Liver Physiol. 2016. PMID 26822915.
  • "PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer.". Tumour Biol. 2016. PMID 26546433.

Cyfeiriadau

  1. ↑ "Human PubMed Reference:".
  2. ↑ PRSS1 - Cronfa NCBI

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