PRND

1LG4

PRND
PRND
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauPRND, DOPPEL, DPL, PrPLP, dJ1068H6.4, prion protein 2 (dublet), prion like protein doppel
Dynodwyr allanolOMIM: 604263 HomoloGene: 8236 GeneCards: PRND
Patrwm RNA pattern
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez

23627

n/a

Ensembl

ENSG00000171864

n/a

UniProt

Q9UKY0

n/a

RefSeq (mRNA)

NM_012409

n/a

RefSeq (protein)

NP_036541

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRND yw PRND a elwir hefyd yn Prion like protein doppel (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20p13.[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRND.

  • DPL
  • PrPLP
  • DOPPEL
  • dJ1068H6.4

Llyfryddiaeth

  • "Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein. ". Acta Biochim Biophys Sin (Shanghai). 2009. PMID 19129949.
  • "The doppel (Dpl) protein influences in vitro migration capability in astrocytoma-derived cells. ". Cell Oncol. 2008. PMID 18936526.
  • "Targeting prion-like protein doppel selectively suppresses tumor angiogenesis. ". J Clin Invest. 2016. PMID 26950422.
  • "PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease. ". Prion. 2012. PMID 22453181.
  • "Biochemical signatures of doppel protein in human astrocytomas to support prediction in tumor malignancy.". J Biomed Biotechnol. 2010. PMID 20981146.

Cyfeiriadau

  1. ↑ "Human PubMed Reference:".
  2. ↑ PRND - Cronfa NCBI

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