PRKCQ

PRKCQ
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1XJD, 2ENJ, 2ENN, 2ENZ, 2JED, 4Q9Z, 4RA5, 5F9E
Dynodwyr
Cyfenwau	PRKCQ, PRKCT, nPKC-theta, protein kinase C theta
Dynodwyr allanol	OMIM: 600448 HomoloGene: 21263 GeneCards: PRKCQ
EC number	2.7.11.13
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase C activity • metal ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • protein serine/threonine kinase activity • protein kinase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • cellbilen • intracellular anatomical structure • immunological synapse • microtubule organizing center • aggresome Prosesau biolegol • GO:0007243 intracellular signal transduction • GO:0009373 regulation of transcription, DNA-templated • positive regulation of telomere capping • phosphorylation • proses y system imiwnedd • positive regulation of telomere maintenance via telomerase • positive regulation of T-helper 2 cell activation • positive regulation of interleukin-4 production • axon guidance • platelet activation • Fc-epsilon receptor signaling pathway • protein phosphorylation • negative regulation of T cell apoptotic process • GO:1903105 negative regulation of insulin receptor signaling pathway • positive regulation of T cell activation • membrane protein ectodomain proteolysis • positive regulation of NF-kappaB transcription factor activity • GO:0035404 peptidyl-serine phosphorylation • positive regulation of T-helper 17 type immune response • regulation of cell growth • positive regulation of T cell proliferation • positive regulation of telomerase activity • cell chemotaxis • positive regulation of interleukin-17 production • inflammatory response • T cell receptor signaling pathway • regulation of platelet aggregation • regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5588	n/a
Ensembl	ENSG00000065675	n/a
UniProt	Q04759	n/a
RefSeq (mRNA)	NM_001242413 NM_001282644 NM_001282645 NM_006257 NM_001323265 NM_001323266 NM_001323267	n/a
RefSeq (protein)	NP_001229342 NP_001269573 NP_001269574 NP_001310194 NP_001310195 NP_001310196 NP_006248	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKCQ yw PRKCQ a elwir hefyd yn Protein kinase C theta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10p15.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKCQ.

• PRKCT
• nPKC-theta

• "Chromatinized protein kinase C-θ directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells. ". Mol Cell Biol. 2014. PMID 24891615.
• "PKCθ regulates T cell motility via ezrin-radixin-moesin localization to the uropod. ". PLoS One. 2013. PMID 24250818.
• "PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells. ". Breast Cancer Res. 2016. PMID 27663795.
• "Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit. ". J Med Chem. 2015. PMID 25000588.
• "Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans.". Proc Natl Acad Sci U S A. 2014. PMID 24979806.