PPM1K

PPM1K
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IQ1, 4DA1
Dynodwyr
Cyfenwau	PPM1K, BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07, protein phosphatase, Mg2+/Mn2+ dependent 1K
Dynodwyr allanol	OMIM: 611065 HomoloGene: 36819 GeneCards: PPM1K
EC number	3.1.3.52 3.1.3.16, 3.1.3.52
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein serine/threonine phosphatase activity • GO:0001948, GO:0016582 protein binding • catalytic activity • phosphoprotein phosphatase activity • hydrolase activity • metal ion binding • cation binding Cydrannau o'r gell • mitochondrial matrix • mitocondria Prosesau biolegol • GO:0016576 protein dephosphorylation • branched-chain amino acid catabolic process • positive regulation of pyruvate dehydrogenase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	152926	n/a
Ensembl	ENSG00000163644	n/a
UniProt	Q8N3J5	n/a
RefSeq (mRNA)	NM_152542	n/a
RefSeq (protein)	NP_689755	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPM1K yw PPM1K a elwir hefyd yn Protein phosphatase 1K (PP2C domain containing), isoform CRA_b a Protein phosphatase, Mg2+/Mn2+ dependent 1K (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q22.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPM1K.

• "Identification of a novel PP2C-type mitochondrial phosphatase. ". Biochem Biophys Res Commun. 2007. PMID 17336929.
• "Characterization of a novel human protein phosphatase 2C family member, PP2Ckappa. ". Int J Mol Med. 2006. PMID 16685424.
• "Effect of the interaction between diet composition and the PPM1Kgenetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial. ". Am J Clin Nutr. 2017. PMID 28768654.
• "Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial. ". Circulation. 2013. PMID 23446828.
• "Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase.". J Biol Chem. 2012. PMID 22291014.