PPM1A

PPM1A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A6Q, 3FXJ, 3FXK, 3FXL, 3FXM, 3FXO, 4RA2, 4RAF, 4RAG
Dynodwyr
Cyfenwau	PPM1A, PP2C-ALPHA, PP2CA, PP2Calpha, protein phosphatase, Mg2+/Mn2+ dependent 1A
Dynodwyr allanol	OMIM: 606108 HomoloGene: 56428 GeneCards: PPM1A
EC number	3.1.3.16
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • R-SMAD binding • phosphoprotein phosphatase activity • manganese ion binding • protein serine/threonine phosphatase activity • calmodulin-dependent protein phosphatase activity • signal transducer activity • metal ion binding • catalytic activity • GO:0001948, GO:0016582 protein binding • cation binding • hydrolase activity • magnesium ion binding Cydrannau o'r gell • cytoplasm • bilen • nucleoplasm • cnewyllyn cell • cytosol • cellbilen Prosesau biolegol • cellular response to transforming growth factor beta stimulus • peptidyl-threonine dephosphorylation • negative regulation of SMAD protein complex assembly • GO:0016576 protein dephosphorylation • negative regulation of transforming growth factor beta receptor signaling pathway • Wnt • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of BMP signaling pathway • positive regulation of protein export from nucleus • positive regulation of Wnt signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • N-terminal protein myristoylation • positive regulation of I-kappaB kinase/NF-kappaB signaling • GO:0098501, GO:0098502, GO:0006286 dephosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5494	n/a
Ensembl	ENSG00000100614	n/a
UniProt	P35813	n/a
RefSeq (mRNA)	NM_021003 NM_177951 NM_177952	n/a
RefSeq (protein)	NP_066283 NP_808820 NP_808821	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPM1A yw PPM1A a elwir hefyd yn Protein phosphatase, Mg2+/Mn2+ dependent 1A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPM1A.

• PP2CA
• PP2Calpha
• PP2C-ALPHA

• "Protein phosphatase, Mg2+/Mn2+-dependent 1A controls the innate antiviral and antibacterial response of macrophages during HIV-1 and Mycobacterium tuberculosis infection. ". Oncotarget. 2016. PMID 27004401.
• "Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway. ". Oncotarget. 2014. PMID 25026293.
• "Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry. ". Biochemistry. 2017. PMID 28481111.
• "PPM1A Methylation Is Associated With Vascular Recurrence in Aspirin-Treated Patients. ". Stroke. 2016. PMID 27301936.
• "Phosphatase PPM1A is a novel prognostic marker in pancreatic ductal adenocarcinoma.". Hum Pathol. 2016. PMID 27195906.