PITX2

PITX2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2L7F, 2L7M, 2LKX
Dynodwyr
Cyfenwau	PITX2, ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS, paired like homeodomain 2, ASGD4
Dynodwyr allanol	OMIM: 601542 HomoloGene: 55454 GeneCards: PITX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • identical protein binding • protein homodimerization activity • GO:0000975 transcription cis-regulatory region binding • sequence-specific DNA binding • DNA binding • GO:0001105 transcription coactivator activity • chromatin DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • chromatin binding • ribonucleoprotein complex binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • transcription factor binding • phosphoprotein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • cytoplasm • transcription regulator complex • nucleoplasm Prosesau biolegol • response to vitamin A • female gonad development • vascular associated smooth muscle cell differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • skeletal muscle tissue development • cell proliferation involved in outflow tract morphogenesis • prolactin secreting cell differentiation • in utero embryonic development • pituitary gland development • vasculogenesis • regulation of cell population proliferation • myoblast fusion • hair cell differentiation • spleen development • GO:0009373 regulation of transcription, DNA-templated • transcription by RNA polymerase II • embryonic camera-type eye development • ventricular septum morphogenesis • endodermal digestive tract morphogenesis • determination of left/right symmetry • cardiac muscle tissue development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • subthalamic nucleus development • ventricular cardiac muscle cell development • left/right axis specification • hypothalamus cell migration • animal organ morphogenesis • regulation of cell migration • development of the heart • embryonic digestive tract morphogenesis • branching involved in blood vessel morphogenesis • cardiac muscle cell differentiation • digestive system development • multicellular organism development • atrioventricular valve development • pulmonary vein morphogenesis • cardiac neural crest cell migration involved in outflow tract morphogenesis • embryonic hindlimb morphogenesis • lung development • superior vena cava morphogenesis • positive regulation of DNA binding • extraocular skeletal muscle development • pulmonary myocardium development • deltoid tuberosity development • atrial cardiac muscle tissue morphogenesis • male gonad development • anatomical structure morphogenesis • brain development • neuron differentiation • odontogenesis of dentin-containing tooth • Wnt • left lung morphogenesis • somatotropin secreting cell differentiation • positive regulation of myoblast proliferation • camera-type eye development • response to hormone • odontogenesis • iris morphogenesis • neuron migration • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5308	n/a
Ensembl	ENSG00000164093	n/a
UniProt	Q99697	n/a
RefSeq (mRNA)	NM_000325 NM_001204397 NM_001204398 NM_001204399 NM_153426 NM_153427	n/a
RefSeq (protein)	NP_000316 NP_001191326 NP_001191327 NP_001191328 NP_700475 NP_700476	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PITX2 yw PITX2 a elwir hefyd yn Paired like homeodomain 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q25.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PITX2.

• "Prediction efficiency of PITX2 DNA methylation for prostate cancer survival. ". Genet Mol Res. 2016. PMID 27173224.
• "Novel PITX2 gene mutations in patients with Axenfeld-Rieger syndrome. ". Acta Ophthalmol. 2016. PMID 27009473.
• "Clinical performance validation of PITX2 DNA methylation as prognostic biomarker in patients with head and neck squamous cell carcinoma. ". PLoS One. 2017. PMID 28617833.
• "Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats. ". Transl Res. 2017. PMID 28427903.
• "PITX2 DNA Methylation as Biomarker for Individualized Risk Assessment of Prostate Cancer in Core Biopsies.". J Mol Diagn. 2017. PMID 27939865.