PIM2

PIM2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2IWI, 4X7Q
Dynodwyr
Cyfenwau	PIM2, Pim-2 proto-oncogene, serine/threonine kinase
Dynodwyr allanol	OMIM: 300295 HomoloGene: 17098 GeneCards: PIM2
EC number	2.7.11.1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding;
Cydrannau o'r gell	• cytoplasm;
Prosesau biolegol	• phosphorylation; • male meiotic nuclear division; • response to virus; • negative regulation of apoptotic process; • protein phosphorylation; • regulation of mitotic cell cycle; • protein autophosphorylation; • cell cycle; • cell population proliferation; • negative regulation of cell population proliferation; • GO:0097285 apoptotic process; • apoptotic mitochondrial changes; • positive regulation of autophagy; • positive regulation of macroautophagy; • negative regulation of protein binding; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • protein stabilization; • G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologau
	11040
	n/a
	ENSG00000102096
	n/a
	Q9P1W9
	n/a
	NM_006875
	n/a
	NP_006866
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIM2 yw PIM2 a elwir hefyd yn Pim-2 proto-oncogene, serine/threonine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xp11.23.^[2]

Llyfryddiaeth

"Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors. ". Int J Med Sci. 2015. PMID 26078709.
"Pim-2/mTORC1 Pathway Shapes Inflammatory Capacity in Rheumatoid Arthritis Synovial Cells Exposed to Lipid Peroxidations. ". Biomed Res Int. 2015. PMID 26064888.
"Pim2 is important for regulating DNA damage response in multiple myeloma cells. ". Blood Cancer J. 2016. PMID 27564460.
"Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas. ". Mol Cancer. 2015. PMID 26643319.
"Control of Pim2 kinase stability and expression in transformed human haematopoietic cells.". Biosci Rep. 2015. PMID 26500282.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PIM2 - Cronfa NCBI

[1]

[2]

PIM2

Llyfryddiaeth

Cyfeiriadau

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