PIM1

PIM1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1XQZ, 1XR1, 1XWS, 1YHS, 1YI3, 1YI4, 1YWV, 1YXS, 1YXT, 1YXU, 1YXV, 1YXX, 2BIK, 2BIL, 2BZH, 2BZI, 2BZJ, 2BZK, 2C3I, 2J2I, 2O3P, 2O63, 2O64, 2O65, 2OBJ, 2OI4, 2XIX, 2XIY, 2XIZ, 2XJ0, 2XJ1, 2XJ2, 3A99, 3BGP, 3BGQ, 3BGZ, 3BWF, 3C4E, 3CXW, 3CY2, 3CY3, 3DCV, 3F2A, 3JPV, 3JXW, 3JY0, 3JYA, 3MA3, 3QF9, 3R00, 3R01, 3R02, 3R04, 3T9I, 3UIX, 3UMW, 3UMX, 3VBQ, 3VBT, 3VBV, 3VBW, 3VBX, 3VBY, 3VC4, 3WE8, 4A7C, 4ALU, 4ALV, 4ALW, 4AS0, 4BZN, 4BZO, 4DTK, 4ENX, 4ENY, 4GW8, 4I41, 4IAA, 4JX3, 4JX7, 4K0Y, 4K18, 4K1B, 4LL5, 4LM5, 4MBI, 4MBL, 4MED, 4MTA, 4N6Y, 4N6Z, 4N70, 4RBL, 4RC2, 4RC3, 4RC4, 4RPV, 4TY1, 4WRS, 4WSY, 4WT6, 4XHK, 4XH6, 5C1Q, 5DWR, 5DIA, 5DHJ, 5DGZ, 5EOL, 5IPJ, 5IIS
Dynodwyr
Cyfenwau	PIM1, PIM, Pim-1 proto-oncogene, serine/threonine kinase
Dynodwyr allanol	OMIM: 164960 HomoloGene: 11214 GeneCards: PIM1
EC number	2.7.11.1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • manganese ion binding; • ribosomal small subunit binding; • transcription factor binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • cellbilen; • nucleoplasm; • nucleolus; • cytosol; • cnewyllyn cell;
Prosesau biolegol	• phosphorylation; • negative regulation of apoptotic process; • negative regulation of DNA-binding transcription factor activity; • multicellular organism development; • protein phosphorylation; • hyaluronan metabolic process; • protein autophosphorylation; • cell cycle; • cell population proliferation; • vitamin D receptor signaling pathway; • GO:0097285 apoptotic process; • regulation of mitotic cell cycle; • positive regulation of cardiac muscle cell proliferation; • positive regulation of cardioblast proliferation; • cytokine-mediated signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • protein stabilization; • regulation of hematopoietic stem cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	5292
	n/a
	ENSG00000137193
	n/a
	P11309
	n/a
	NM_002648; NM_001243186
	n/a
	NP_001230115; NP_002639
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIM1 yw PIM1 a elwir hefyd yn Pim-1 proto-oncogene, serine/threonine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PIM1.

PIM

Llyfryddiaeth

"PIM1 gene silencing inhibits proliferation and promotes apoptosis of human esophageal cancer cell line Eca-109. ". Cancer Biomark. 2017. PMID 27983525.
"PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. ". Nat Med. 2016. PMID 27775705.
"PIM kinases: From survival factors to regulators of cell motility. ". Int J Biochem Cell Biol. 2017. PMID 29108877.
"PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells. ". Int J Oncol. 2017. PMID 28197633.
"Cytoplasmic Irradiation Induces Metabolic Shift in Human Small Airway Epithelial Cells via Activation of Pim-1 Kinase.". Radiat Res. 2017. PMID 28170315.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PIM1 - Cronfa NCBI

[1]

[2]

PIM1

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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