PDX1

PDX1
Dynodwyr
Cyfenwau	PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1, pancreatic and duodenal homeobox 1
Dynodwyr allanol	OMIM: 600733 HomoloGene: 175 GeneCards: PDX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • GO:0032403 protein-containing complex binding • protein heterodimerization activity • promoter-specific chromatin binding Cydrannau o'r gell • cytoplasm • cytosol • nuclear speck • intracellular anatomical structure • cnewyllyn cell • nucleoplasm Prosesau biolegol • exocrine pancreas development • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • glucose homeostasis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • insulin secretion • GO:1901227 negative regulation of transcription by RNA polymerase II • generation of precursor metabolites and energy • transcription, DNA-templated • multicellular organism development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of cell population proliferation • positive regulation of cell population proliferation • nitric oxide mediated signal transduction • glucose metabolic process • animal organ morphogenesis • pancreas development • liver development • positive regulation of insulin secretion involved in cellular response to glucose stimulus • morphogenesis of embryonic epithelium • digestive tract development • negative regulation of type B pancreatic cell apoptotic process • negative regulation of cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • endocrine pancreas development • type B pancreatic cell differentiation • transcription by RNA polymerase II • detection of glucose • smoothened signaling pathway • central nervous system development • response to wounding • response to glucose • response to iron(II) ion • response to chlorate • regulation of gene expression • positive regulation of cell death • GO:1904578 response to organic cyclic compound • animal organ regeneration • response to nutrient levels • positive regulation of insulin secretion • response to vitamin • response to lipid • response to cytokine • response to nicotine • response to leucine • response to alkaloid • positive regulation of DNA binding • GO:0045996 negative regulation of transcription, DNA-templated • stem cell differentiation • response to glucocorticoid • transdifferentiation • response to fatty acid Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3651	n/a
Ensembl	ENSG00000139515	n/a
UniProt	P52945	n/a
RefSeq (mRNA)	NM_000209	n/a
RefSeq (protein)	NP_000200	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDX1 yw PDX1 a elwir hefyd yn Pancreatic and duodenal homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q12.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDX1.

• "Dependence of expression of regulatory master genes of embryonic development in pancreatic cancer cells on the intracellular concentration of the master regulator PDX1. ". Dokl Biochem Biophys. 2017. PMID 28864896.
• "Mild electrical stimulation with heat shock guides differentiation of embryonic stem cells into Pdx1-expressing cells within the definitive endoderm. ". BMC Biotechnol. 2017. PMID 28202025.
• "Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma. ". Curr Mol Med. 2016. PMID 26695692.
• "Adult Human Biliary Tree Stem Cells Differentiate to β-Pancreatic Islet Cells by Treatment with a Recombinant Human Pdx1 Peptide. ". PLoS One. 2015. PMID 26252949.
• "PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells.". Stem Cell Reports. 2015. PMID 25843046.