PAX2

PAX2
Dynodwyr
Cyfenwau	PAX2, PAPRS, FSGS7, paired box 2, PAX-2
Dynodwyr allanol	OMIM: 167409 HomoloGene: 2968 GeneCards: PAX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • superoxide-generating NAD(P)H oxidase activity • transcription factor binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity Cydrannau o'r gell • Golgi apparatus • centriolar satellite • microtubule organizing center • protein-DNA complex • nucleolus • lysosome • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • cellular response to hydrogen peroxide • cellular response to glucose stimulus • cochlea development • pronephros development • cellular response to retinoic acid • regulation of metanephric nephron tubule epithelial cell differentiation • animal organ development • ureter development • cell differentiation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of branching involved in ureteric bud morphogenesis • GO:0009373 regulation of transcription, DNA-templated • positive regulation of metanephric DCT cell differentiation • regulation of metanephros size • axonogenesis • protein kinase B signaling • negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis • negative regulation of apoptotic process involved in metanephric collecting duct development • positive regulation of epithelial cell proliferation • optic nerve morphogenesis • pronephric field specification • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • metanephric mesenchymal cell differentiation • GO:0010260 heneiddio • metanephric epithelium development • mesenchymal to epithelial transition involved in metanephros morphogenesis • negative regulation of apoptotic process • glial cell differentiation • transcription by RNA polymerase II • retinal pigment epithelium development • nephric duct formation • transcription, DNA-templated • stem cell differentiation • metanephric distal convoluted tubule development • reactive oxygen species metabolic process • negative regulation of mesenchymal cell apoptotic process involved in metanephros development • mesonephros development • optic nerve structural organization • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • cellular response to epidermal growth factor stimulus • metanephric nephron tubule formation • positive regulation of metanephric glomerulus development • multicellular organism development • branching involved in ureteric bud morphogenesis • neural tube closure • response to nutrient levels • negative regulation of apoptotic process involved in metanephric nephron tubule development • ureter maturation • inner ear morphogenesis • cochlea morphogenesis • positive regulation of optic nerve formation • positive regulation of cell population proliferation • optic cup morphogenesis involved in camera-type eye development • urogenital system development • cell fate determination • negative regulation of programmed cell death • vestibulocochlear nerve formation • camera-type eye development • metanephric collecting duct development • negative regulation of reactive oxygen species metabolic process • mesodermal cell fate specification • GO:0045996 negative regulation of transcription, DNA-templated • metanephric mesenchyme development • optic chiasma development • optic nerve development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • golwg • negative regulation of cytolysis • brain morphogenesis • mesenchymal to epithelial transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5076	n/a
Ensembl	ENSG00000075891	n/a
UniProt	Q02962 Q5SZP1	n/a
RefSeq (mRNA)	NM_003990 NM_000278 NM_001304569 NM_003987 NM_003988 NM_003989 NM_001374303	n/a
RefSeq (protein)	NP_000269 NP_001291498 NP_003978 NP_003979 NP_003980 NP_003981 NP_001361232	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAX2 yw PAX2 a elwir hefyd yn Paired box protein Pax-2 a Paired box 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q24.31.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAX2.

• FSGS7
• PAPRS

• "Association of PAX2 and Other Gene Mutations with the Clinical Manifestations of Renal Coloboma Syndrome. ". PLoS One. 2015. PMID 26571382.
• "The significance of Pax2 expression in the ureter epithelium of children with vesicoureteric reflux. ". Hum Pathol. 2015. PMID 25912758.
• "Rethinking genotype-phenotype correlations in papillorenal syndrome: a case report on an unusual congenital camptodactyly and skeletal deformity with a heterogeneous PAX2 mutation of hexanucleotide duplication. ". Gene. 2018. PMID 29054766.
• "Genetic association between PAX2 and mullerian duct anomalies in Han Chinese females. ". J Assist Reprod Genet. 2017. PMID 27722936.
• "[Influence of PAX2 gene silencing on renal interstitial fibrosis in rats].". Zhongguo Dang Dai Er Ke Za Zhi. 2016. PMID 27324546.