PARVA

PARVA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K2R, 2VZC, 2VZD, 2VZG, 2VZI, 3KMU, 3KMW, 3REP
Dynodwyr
Cyfenwau	PARVA, CH-ILKBP, MXRA2, parvin alpha
Dynodwyr allanol	OMIM: 608120 HomoloGene: 10077 GeneCards: PARVA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • actin binding • cadherin binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • cellbilen • cell junction • Z discdkac • Cytosgerbwd • focal adhesion • actin cytoskeleton • cnewyllyn cell • lamellipodium Prosesau biolegol • actin cytoskeleton reorganization • cilium assembly • smooth muscle cell chemotaxis • heterotypic cell-cell adhesion • sprouting angiogenesis • outflow tract septum morphogenesis • establishment or maintenance of cell polarity • chemotaxis • actin-mediated cell contraction • cell adhesion • cell projection organization • angiogenesis • regulation of cell shape • substrate adhesion-dependent cell spreading • cell projection assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	55742	n/a
Ensembl	ENSG00000197702	n/a
UniProt	Q9NVD7	n/a
RefSeq (mRNA)	NM_018222	n/a
RefSeq (protein)	NP_060692	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARVA yw PARVA a elwir hefyd yn Alpha-parvin a Parvin alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARVA.

• MXRA2
• CH-ILKBP

• "Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion. ". J Biol Chem. 2012. PMID 22955285.
• "Involvement of β1-integrin via PIP complex and FAK/paxillin in dexamethasone-induced human mesenchymal stem cells migration. ". J Cell Physiol. 2011. PMID 20717960.
• "α-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma. ". Breast Cancer Res Treat. 2014. PMID 24496929.
• "Suppression of actopaxin impairs hepatocellular carcinoma metastasis through modulation of cell migration and invasion. ". Hepatology. 2013. PMID 23504997.
• "Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation.". PLoS One. 2012. PMID 23056266.