PAPSS1

PAPSS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X6V, 1XJQ, 1XNJ, 2OFW, 2OFX, 2PEY, 2PEZ, 2QJF
Dynodwyr
Cyfenwau	PAPSS1, ATPSK1, PAPSS, SK1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Dynodwyr allanol	OMIM: 603262 HomoloGene: 81740 GeneCards: PAPSS1
EC number	2.7.7.4 2.7.1.25, 2.7.7.4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • nucleotidyltransferase activity • catalytic activity • ATP binding • kinase activity • sulfate adenylyltransferase (ATP) activity • protein homodimerization activity • adenylylsulfate kinase activity Cydrannau o'r gell • cytosol Prosesau biolegol • skeletal system development • metabolaeth • phosphorylation • sulfate assimilation • 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9061	n/a
Ensembl	ENSG00000138801	n/a
UniProt	O43252	n/a
RefSeq (mRNA)	NM_005443	n/a
RefSeq (protein)	NP_005434	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PAPSS1 yw PAPSS1 a elwir hefyd yn 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q25.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PAPSS1.

• SK1
• PAPSS
• ATPSK1

• "The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment. ". PLoS Pathog. 2008. PMID 19008949.
• "Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation. ". J Biol Chem. 2007. PMID 17540769.
• "Sphingosine kinase 1 and cancer: a systematic review and meta-analysis. ". PLoS One. 2014. PMID 24587339.
• "Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. ". FASEB J. 2010. PMID 20335228.
• "Evidence for association with hepatocellular carcinoma at the PAPSS1 locus on chromosome 4q25 in a family-based study.". Eur J Hum Genet. 2009. PMID 19337310.