OTUB2

1TFF, 4FJV

OTUB2
OTUB2
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauOTUB2, C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2
Dynodwyr allanolOMIM: 608338 HomoloGene: 57056 GeneCards: OTUB2
EC number3.4.19.12
Patrwm RNA pattern
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez

78990

n/a

Ensembl

ENSG00000089723
ENSG00000277276

n/a

UniProt

Q96DC9

n/a

RefSeq (mRNA)

NM_023112

n/a

RefSeq (protein)

NP_075601

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn OTUB2 yw OTUB2 a elwir hefyd yn OTU deubiquitinase, ubiquitin aldehyde binding 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.12.[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn OTUB2.

  • OTB2
  • OTU2
  • C14orf137

Llyfryddiaeth

  • "Otubains: a new family of cysteine proteases in the ubiquitin pathway. ". EMBO Rep. 2003. PMID 12704427.
  • "The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages. ". PLoS One. 2015. PMID 25590432.
  • "Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice. ". Mol Cell. 2014. PMID 24560272.
  • "Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets. ". Diabetologia. 2013. PMID 23515685.
  • "Crystal structure of human otubain 2.". EMBO Rep. 2004. PMID 15258613.

Cyfeiriadau

  1. ↑ "Human PubMed Reference:".
  2. ↑ OTUB2 - Cronfa NCBI

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