NUDT21

NUDT21
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CL3, 2J8Q, 3BAP, 3BHO, 3MDG, 3MDI, 3N9U, 3P5T, 3P6Y, 3Q2S, 3Q2T
Dynodwyr
Cyfenwau	NUDT21, CFIM25, CPSF5, nudix hydrolase 21
Dynodwyr allanol	OMIM: 604978 HomoloGene: 5090 GeneCards: NUDT21
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • histone deacetylase binding • GO:0001948, GO:0016582 protein binding • mRNA binding • hydrolase activity • RNA binding • identical protein binding • chromatin binding • mRNA 3'-UTR AU-rich region binding Cydrannau o'r gell • paraspeckles • centrosome • nucleoplasm • microtubule organizing center • mRNA cleavage factor complex • cnewyllyn cell • nuclear body • cytoplasm • mRNA cleavage and polyadenylation specificity factor complex Prosesau biolegol • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • protein tetramerization • mRNA 3'-end processing • mRNA polyadenylation • mRNA processing • posttranscriptional regulation of gene expression • cell differentiation • positive regulation of mRNA cleavage • protein heterotetramerization • pre-mRNA cleavage required for polyadenylation • mRNA alternative polyadenylation • positive regulation of mRNA polyadenylation • messenger ribonucleoprotein complex assembly • positive regulation of stem cell differentiation • positive regulation of pro-B cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11051	n/a
Ensembl	ENSG00000167005	n/a
UniProt	O43809	n/a
RefSeq (mRNA)	NM_007006	n/a
RefSeq (protein)	NP_008937	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NUDT21 yw NUDT21 a elwir hefyd yn Nudix hydrolase 21 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16q13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NUDT21.

• CPSF5
• CFIM25

• "Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs. ". Nucleic Acids Res. 2006. PMID 17098938.
• "MicroRNA-181a promotes proliferation and inhibits apoptosis by suppressing CFIm25 in osteosarcoma. ". Mol Med Rep. 2016. PMID 27633853.
• "NUDT21 regulates 3'-UTR length and microRNA-mediated gene silencing in hepatocellular carcinoma. ". Cancer Lett. 2017. PMID 28964783.
• "The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site. ". Proteins. 2008. PMID 18767156.
• "Crystal structure of the 25 kDa subunit of human cleavage factor Im.". Nucleic Acids Res. 2008. PMID 18445629.