NOTCH2

NOTCH2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2OO4
Dynodwyr
Cyfenwau	NOTCH2, AGS2, HJCYS, hN2, Notch-2, notch 2, notch receptor 2
Dynodwyr allanol	OMIM: 600275 HomoloGene: 7865 GeneCards: NOTCH2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • GO:0001948, GO:0016582 protein binding; • signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • endoplasmic reticulum membrane; • bilen; • Golgi membrane; • receptor complex; • cellbilen; • integral component of plasma membrane; • nucleoplasm; • extracellular region; • cell surface; • cnewyllyn cell;
Prosesau biolegol	• Notch signaling pathway; • cell differentiation; • hemopoiesis; • pulmonary valve morphogenesis; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of Ras protein signal transduction; • negative regulation of apoptotic process; • marginal zone B cell differentiation; • transcription, DNA-templated; • nervous system development; • stem cell population maintenance; • multicellular organism development; • atrial septum morphogenesis; • GO:0090343, GO:0090342 regulation of developmental process; • bone remodeling; • animal organ morphogenesis; • transcription initiation from RNA polymerase II promoter; • Notch signaling involved in heart development; • GO:0097285 apoptotic process; • cell fate determination; • intracellular receptor signaling pathway; • negative regulation of gene expression; • negative regulation of growth rate; • positive regulation of ERK1 and ERK2 cascade; • regulation of osteoclast development; • positive regulation of keratinocyte proliferation; • regulation of actin cytoskeleton reorganization;
	Sources:Amigo / QuickGO
Orthologau
	4853
	n/a
	ENSG00000134250
	n/a
	Q04721
	n/a
	NM_001200001; NM_024408
	n/a
	NP_001186930; NP_077719
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NOTCH2 yw NOTCH2 a elwir hefyd yn Notch 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NOTCH2.

hN2
AGS2
HJCYS

Llyfryddiaeth

"An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD. ". Blood. 2017. PMID 28851699.
"Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells. ". Oncol Rep. 2016. PMID 27221981.
"Notch2 signaling contributes to cell growth, invasion, and migration in salivary adenoid cystic carcinoma. ". Mol Cell Biochem. 2016. PMID 26427670.
"NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells. ". Oncol Rep. 2015. PMID 26252838.
"A novel NOTCH2 mutation identified in a Korean family with Hajdu-Cheney syndrome showing phenotypic diversity.". Ann Clin Lab Sci. 2015. PMID 25696021.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NOTCH2 - Cronfa NCBI

[1]

[2]

NOTCH2

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

Content Disclaimer