NOTCH1

NOTCH1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PB5, 1TOZ, 1YYH, 2F8X, 2F8Y, 2HE0, 2VJ3, 3ETO, 3I08, 3L95, 3NBN, 3V79, 4CUD, 4CUE, 4CUF, 4D0E, 4D0F, 5FM9, 5FMA
Dynodwyr
Cyfenwau	NOTCH1, Notch1, 9930111A19Rik, Mis6, N1, Tan1, lin-12, AOS5, AOVD1, hN1, notch 1, notch receptor 1
Dynodwyr allanol	OMIM: 190198 HomoloGene: 32049 GeneCards: NOTCH1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • Notch binding • GO:0048551 enzyme inhibitor activity • metal ion binding • enzyme binding • chromatin binding • GO:0001948, GO:0016582 protein binding • sequence-specific DNA binding • protein heterodimerization activity • chromatin DNA binding • transmembrane signaling receptor activity • signaling receptor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cytosol • bilen • adherens junction • extracellular region • cnewyllyn cell • cell surface • apical plasma membrane • Reticwlwm endoplasmig • integral component of membrane • Golgi apparatus • receptor complex • cellbilen • nucleoplasm • MAML1-RBP-Jkappa- ICN1 complex • cyrion cell • endoplasmic reticulum membrane • Golgi membrane • acrosomal vesicle • GO:0016023 cytoplasmic vesicle Prosesau biolegol • cardiac vascular smooth muscle cell development • endoderm development • pulmonary valve morphogenesis • positive regulation of endothelial cell differentiation • regulation of somitogenesis • cell differentiation in spinal cord • negative regulation of neuron differentiation • regulation of extracellular matrix assembly • distal tubule development • negative regulation of glial cell proliferation • epithelial to mesenchymal transition involved in endocardial cushion formation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • aortic valve morphogenesis • oligodendrocyte differentiation • endocardium morphogenesis • negative regulation of osteoblast differentiation • negative regulation of stem cell differentiation • negative regulation of ossification • heart looping • negative regulation of photoreceptor cell differentiation • arterial endothelial cell differentiation • atrioventricular valve morphogenesis • Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation • humoral immune response • foregut morphogenesis • negative regulation of oligodendrocyte differentiation • positive regulation of cardiac muscle cell proliferation • GO:0090343, GO:0090342 regulation of developmental process • mesenchymal cell development • animal organ regeneration • angiogenesis • spermatogenesis • negative regulation of pro-B cell differentiation • regulation of cardioblast proliferation • hair follicle morphogenesis • vasculogenesis involved in coronary vascular morphogenesis • negative regulation of canonical Wnt signaling pathway • regulation of neurogenesis • negative regulation of cell population proliferation • collecting duct development • positive regulation of neuroblast proliferation • cilium assembly • heart trabecula morphogenesis • atrioventricular node development • negative regulation of myoblast differentiation • cell fate commitment • GO:0009373 regulation of transcription, DNA-templated • cellular response to follicle-stimulating hormone stimulus • lung development • negative regulation of inner ear auditory receptor cell differentiation • cardiac septum morphogenesis • ventricular septum morphogenesis • negative regulation of cell differentiation • coronary artery morphogenesis • response to muramyl dipeptide • cardiac left ventricle morphogenesis • in utero embryonic development • negative regulation of cell death • endocardial cell differentiation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • development of the heart • prostate gland epithelium morphogenesis • embryonic limb morphogenesis • growth involved in heart morphogenesis • neural tube development • pericardium morphogenesis • epidermis development • cardiac atrium morphogenesis • transcription initiation from RNA polymerase II promoter • cardiac right atrium morphogenesis • negative regulation of cell-substrate adhesion • cell migration involved in endocardial cushion formation • cell differentiation • venous endothelial cell differentiation • regulation of inner ear auditory receptor cell differentiation • GO:0048553 negative regulation of catalytic activity • inflammatory response to antigenic stimulus • positive regulation of astrocyte differentiation • positive regulation of epithelial cell proliferation • cardiac right ventricle formation • endocardial cushion development • cell fate specification • positive regulation of keratinocyte differentiation • positive regulation of glial cell differentiation • negative regulation of neurogenesis • glomerular mesangial cell development • sprouting angiogenesis • glial cell differentiation • GO:1901227 negative regulation of transcription by RNA polymerase II • cardiac muscle cell proliferation • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development • positive regulation of epithelial to mesenchymal transition • ventricular trabecula myocardium morphogenesis • neuronal stem cell population maintenance • negative regulation of cell migration involved in sprouting angiogenesis • response to lipopolysaccharide • compartment pattern specification • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • neuron differentiation • epithelial to mesenchymal transition • positive regulation of BMP signaling pathway • skeletal muscle cell differentiation • regulation of gene expression • positive regulation of viral genome replication • regulation of epithelial cell proliferation involved in prostate gland development • GO:0045996 negative regulation of transcription, DNA-templated • cardiac ventricle morphogenesis • branching morphogenesis of an epithelial tube • positive regulation of receptor signaling pathway via JAK-STAT • negative regulation of anoikis • Notch signaling involved in heart development • coronary vein morphogenesis • apoptotic process involved in embryonic digit morphogenesis • regulation of cell migration • axonogenesis • tissue regeneration • positive regulation of cell migration • somatic stem cell division • cardiac muscle tissue morphogenesis • negative regulation of endothelial cell chemotaxis • keratinocyte differentiation • negative regulation of BMP signaling pathway • endocardial cushion morphogenesis • endocardium development • multicellular organism development • auditory receptor cell fate commitment • response to corticosteroid • tube formation • determination of left/right symmetry • astrocyte differentiation • negative regulation of calcium ion-dependent exocytosis • brain development • regulation of cell population proliferation • positive regulation of cell population proliferation • negative regulation of myotube differentiation • positive regulation of apoptotic process • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • mitral valve formation • liver development • cardiac chamber formation • forebrain development • cellular response to vascular endothelial growth factor stimulus • neuron fate commitment • regulation of epithelial cell proliferation • regulation of Notch signaling pathway • left/right axis specification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cardiac epithelial to mesenchymal transition • embryonic hindlimb morphogenesis • positive regulation of aorta morphogenesis • venous blood vessel morphogenesis • Notch signaling pathway • negative regulation of gene expression • negative regulation of growth rate • positive regulation of Ras protein signal transduction • positive regulation of ERK1 and ERK2 cascade • positive regulation of transcription of Notch receptor target • positive regulation of Notch signaling pathway • outflow tract morphogenesis • coronary sinus valve morphogenesis • negative regulation of cell proliferation involved in heart valve morphogenesis • negative regulation of extracellular matrix constituent secretion • negative regulation of cardiac muscle hypertrophy • GO:1901313 positive regulation of gene expression • homeostasis of number of cells within a tissue • negative regulation of biomineral tissue development • positive regulation of apoptotic process involved in morphogenesis • positive regulation of cardiac epithelial to mesenchymal transition • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4851	n/a
Ensembl	ENSG00000148400	n/a
UniProt	P46531	n/a
RefSeq (mRNA)	NM_017617	n/a
RefSeq (protein)	NP_060087	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NOTCH1 yw NOTCH1 a elwir hefyd yn Notch 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q34.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NOTCH1.

• "Correlation between histone acetylation and expression of Notch1 in human lung carcinoma and its possible role in combined small-cell lung carcinoma. ". Lab Invest. 2017. PMID 28414324.
• "Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure. ". J Biol Chem. 2017. PMID 28302721.
• "Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. ". Am J Surg Pathol. 2017. PMID 28914715.
• "Notch1 signaling induces epithelial-mesenchymal transition in lens epithelium cells during hypoxia. ". BMC Ophthalmol. 2017. PMID 28764685.
• "Hypoplastic Left Heart Syndrome Sequencing Reveals a Novel NOTCH1 Mutation in a Family with Single Ventricle Defects.". Pediatr Cardiol. 2017. PMID 28608148.