NGFR

NGFR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3EWV, 2N80, 2N97, 2N83
Dynodwyr
Cyfenwau	NGFR, CD271, Gp80-LTNFRSF16, p75(NTR), p75NTR, nerve growth factor receptor
Dynodwyr allanol	OMIM: 162010 HomoloGene: 1877 GeneCards: NGFR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signal transducer activity • transmembrane signaling receptor activity • tumor necrosis factor-activated receptor activity • ubiquitin protein ligase binding • GO:0001948, GO:0016582 protein binding • calmodulin binding • coreceptor activity • neurotrophin binding • nerve growth factor binding • amyloid-beta binding • death receptor activity • signaling receptor activity Cydrannau o'r gell • extracellular region • nucleoplasm • integral component of membrane • cytosol • integral component of plasma membrane • neuron projection • bilen • cell surface • endosome • cnewyllyn cell • cellbilen Prosesau biolegol • proses rythmig • regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of apoptotic process • neurotrophin TRK receptor signaling pathway • GO:0072468 signal transduction • axon guidance • multicellular organism development • GO:0097285 apoptotic process • negative regulation of axonogenesis • nervous system development • glucose homeostasis • positive regulation of axonogenesis • circadian regulation of gene expression • membrane protein intracellular domain proteolysis • cell differentiation • inflammatory response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • intracellular protein transport • positive regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • tumor necrosis factor-mediated signaling pathway • response to lipopolysaccharide • apoptotic signaling pathway • negative regulation of neuron projection development • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein localization to nucleus • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • Rho protein signal transduction • cellular glucose homeostasis • neuron apoptotic process • cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4804	n/a
Ensembl	ENSG00000064300	n/a
UniProt	P08138	n/a
RefSeq (mRNA)	NM_002507	n/a
RefSeq (protein)	NP_002498	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NGFR yw NGFR a elwir hefyd yn Nerve growth factor receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.33.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NGFR.

• "Clinical Relevance of a Candidate Stem Cell Marker, p75 Neurotrophin Receptor (p75NTR) Expression in Circulating Tumor Cells. ". Adv Exp Med Biol. 2017. PMID 28560678.
• "The Role of Neurotrophin Signaling in Gliomagenesis: A Focus on the p75 Neurotrophin Receptor (p75NTR/CD271). ". Vitam Horm. 2017. PMID 28215302.
• "Defective autophagy leads to the suppression of stem-like features of CD271+ osteosarcoma cells. ". J Biomed Sci. 2016. PMID 27863492.
• "Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells. ". Int J Dev Neurosci. 2016. PMID 27469433.
• "CD271 Down-Regulation Promotes Melanoma Progression and Invasion in Three-Dimensional Models and in Zebrafish.". J Invest Dermatol. 2016. PMID 27328305.