NFE2

NFE2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KZ5
Dynodwyr
Cyfenwau	NFE2, NF-E2, p45, nuclear factor, erythroid 2
Dynodwyr allanol	OMIM: 601490 HomoloGene: 4491 GeneCards: NFE2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein N-terminus binding • GO:0001105 transcription coactivator activity • GO:0000975 transcription cis-regulatory region binding • GO:0001948, GO:0016582 protein binding • WW domain binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • PML body • cnewyllyn cell • nucleoplasm • protein-DNA complex Prosesau biolegol • hemostasis • GO:0009373 regulation of transcription, DNA-templated • blood coagulation • blood circulation • transcription, DNA-templated • multicellular organism development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • nucleosome disassembly • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4778	n/a
Ensembl	ENSG00000123405	n/a
UniProt	Q16621	n/a
RefSeq (mRNA)	NM_001136023 NM_001261461 NM_006163 NM_001400365 NM_001400372 NM_001400373	n/a
RefSeq (protein)	NP_001129495 NP_001248390 NP_006154	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NFE2 yw NFE2 a elwir hefyd yn Nuclear factor, erythroid 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.13.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NFE2.

• p45
• NF-E2

• "A novel role for nuclear factor-erythroid 2 in erythroid maturation by modulation of mitochondrial autophagy. ". Haematologica. 2016. PMID 27479815.
• "[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis]. ". Pathologe. 2013. PMID 24196613.
• "Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates prefibrotic primary myelofibrosis from essential thrombocythemia. ". Blood. 2013. PMID 23670178.
• "MPN patients harbor recurrent truncating mutations in transcription factor NF-E2. ". J Exp Med. 2013. PMID 23589569.
• "Elevated nuclear factor erythroid-2 levels promote epo-independent erythroid maturation and recapitulate the hematopoietic stem cell and common myeloid progenitor expansion observed in polycythemia vera patients.". Stem Cells Transl Med. 2013. PMID 23341442.