NFATC1

NFATC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A66, 1NFA
Dynodwyr
Cyfenwau	NFATC1, NF-ATC, NFAT2, NFATc, NF-ATc1.2, nuclear factor of activated T-cells 1, nuclear factor of activated T cells 1
Dynodwyr allanol	OMIM: 600489 HomoloGene: 32336 GeneCards: NFATC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • mitogen-activated protein kinase p38 binding • FK506 binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin binding • transcription factor binding Cydrannau o'r gell • cytoplasm • cytosol • cnewyllyn cell • nucleoplasm • nuclear body • transcription regulator complex Prosesau biolegol • GO:0007243 intracellular signal transduction • GO:0009373 regulation of transcription, DNA-templated • calcineurin-NFAT signaling cascade • transcription by RNA polymerase II • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • Fc-epsilon receptor signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • Wnt signaling pathway, calcium modulating pathway • negative regulation of Wnt signaling pathway • negative regulation of vascular associated smooth muscle cell differentiation • GO:0032617 cytokine production • aortic valve morphogenesis • pulmonary valve morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4772	n/a
Ensembl	ENSG00000131196	n/a
UniProt	O95644	n/a
RefSeq (mRNA)	NM_172390 NM_001278669 NM_001278670 NM_001278672 NM_001278673 NM_001278675 NM_006162 NM_172387 NM_172388 NM_172389	n/a
RefSeq (protein)	NP_001265598 NP_001265599 NP_001265601 NP_001265602 NP_001265604 NP_006153 NP_765975 NP_765976 NP_765977 NP_765978	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NFATC1 yw NFATC1 a elwir hefyd yn Nuclear factor of activated T-cells 1 a Nuclear factor of-activated T-cells, cytoplasmic 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18q23.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NFATC1.

• "Src-family kinases negatively regulate NFAT signaling in resting human T cells. ". PLoS One. 2017. PMID 29073235.
• "NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients. ". Pharmacogenomics. 2017. PMID 28244807.
• "Defining a new aggressiveness classification and using NFATc1 localization as a prognostic factor in cherubism. ". Hum Pathol. 2016. PMID 27498064.
• "The role of nuclear factor of activated T cells during phorbol myristate acetate-induced cardiac differentiation of mesenchymal stem cells. ". Stem Cell Res Ther. 2016. PMID 27405982.
• "NFATc1 regulates cell proliferation, migration, and invasion of ovarian cancer SKOV3 cells in vitro and in vivo.". Oncol Rep. 2016. PMID 27350254.