NEK2

NEK2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2JAV, 2W5A, 2W5B, 2WQO, 2XK3, 2XK4, 2XK6, 2XK7, 2XK8, 2XKC, 2XKD, 2XKE, 2XKF, 2XNM, 2XNN, 2XNO, 2XNP, 4A4X, 4AFE
Dynodwyr
Cyfenwau	NEK2, HsPK21, NEK2A, NLK1, PPP1R111, RP67, NIMA related kinase 2
Dynodwyr allanol	OMIM: 604043 HomoloGene: 74441 GeneCards: NEK2
EC number	2.7.11.1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • protein phosphatase binding; • ATP binding;
Cydrannau o'r gell	• cytosol; • centrosome; • spindle pole; • Cromosom; • condensed nuclear chromosome; • microtubule organizing center; • midbody; • nucleolus; • microtubule; • chromosome, centromeric region; • Cytosgerbwd; • kinetochore; • nucleoplasm; • cnewyllyn cell; • cytoplasm; • GO:0009327 protein-containing complex;
Prosesau biolegol	• positive regulation of telomere capping; • regulation of mitotic centrosome separation; • phosphorylation; • chromosome segregation; • negative regulation of DNA binding; • positive regulation of telomere maintenance via telomerase; • spindle assembly; • Cellraniad; • protein phosphorylation; • mitotic spindle assembly; • G2/M transition of mitotic cell cycle; • GO:0007126 Meiosis; • positive regulation of telomerase activity; • centrosome separation; • mitotic sister chromatid segregation; • protein autophosphorylation; • cell cycle; • negative regulation of centriole-centriole cohesion; • regulation of attachment of spindle microtubules to kinetochore; • blastocyst development; • regulation of mitotic nuclear division; • ciliary basal body-plasma membrane docking; • GO:0007067 Mitosis; • regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologau
	4751
	n/a
	ENSG00000117650
	n/a
	P51955
	n/a
	NM_001204182; NM_001204183; NM_002497
	n/a
	NP_001191111; NP_001191112; NP_002488
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NEK2 yw NEK2 a elwir hefyd yn NIMA related kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q32.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NEK2.

NLK1
RP67
NEK2A
HsPK21
PPP1R111

Llyfryddiaeth

"Effect of NIMA-related kinase 2B on the sensitivity of breast cancer to paclitaxel in vitro and vivo. ". Tumour Biol. 2017. PMID 28475000.
"NEK2 serves as a prognostic biomarker for hepatocellular carcinoma. ". Int J Oncol. 2017. PMID 28101574.
"Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression. ". Int J Cancer. 2017. PMID 27925179.
"NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma. ". Oncol Rep. 2016. PMID 27349376.
"Targeting NEK2 as a promising therapeutic approach for cancer treatment.". Cell Cycle. 2016. PMID 27019372.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NEK2 - Cronfa NCBI

[1]

[2]

NEK2

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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