MTR

MTR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2O2K, 4CCZ
Dynodwyr
Cyfenwau	MTR, HMAG, MS, cblG, 5-methyltetrahydrofolate-homocysteine methyltransferase
Dynodwyr allanol	OMIM: 156570 HomoloGene: 37280 GeneCards: MTR
EC number	2.1.1.13
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • GO:0001948, GO:0016582 protein binding • methionine synthase activity • zinc ion binding • cobalamin binding • metal ion binding • transferase activity Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • nervous system development • pteridine-containing compound metabolic process • methionine biosynthetic process • response to axon injury • cellular amino acid biosynthetic process • cobalamin metabolic process • cellular response to nitric oxide • axon regeneration • metaboledd celloedd • methylation • sulfur amino acid metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4548	n/a
Ensembl	ENSG00000116984	n/a
UniProt	Q99707	n/a
RefSeq (mRNA)	NM_000254 NM_001291939 NM_001291940	n/a
RefSeq (protein)	NP_000245 NP_001278868 NP_001278869	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MTR yw MTR a elwir hefyd yn 5-methyltetrahydrofolate-homocysteine methyltransferase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q43.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MTR.

• MS
• HMAG
• cblG

• "Methionine synthase 2756AA polymorphism is associated with the risk of cognitive impairment in patients with late-life depression. ". Asia Pac Psychiatry. 2017. PMID 27111719.
• "Methionine synthase A2756G transition might be a risk factor for male infertility: Evidences from seven case-control studies. ". Mol Cell Endocrinol. 2016. PMID 26905524.
• "Methionine synthase A2756G variation is associated with the risk of retinoblastoma in Iranian children. ". Cancer Epidemiol. 2015. PMID 26595280.
• "Genetic variants of methionine metabolism and DNA methylation. ". Epigenomics. 2014. PMID 25531253.
• "Quantitative assessment of the association between MS gene polymorphism and colorectal cancer risk.". Cell Biochem Biophys. 2014. PMID 25077679.