MSX2

MSX2
Dynodwyr
Cyfenwau	MSX2, CRS2, FPP, HOX8, MSH, PFM, PFM1, Msh homeobox 2
Dynodwyr allanol	OMIM: 123101 HomoloGene: 1837 GeneCards: MSX2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• sequence-specific DNA binding; • DNA binding; • GO:0001104 transcription coregulator activity; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • transcription factor binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cnewyllyn cell; • cytosol; • nuclear speck;
Prosesau biolegol	• negative regulation of cell population proliferation; • positive regulation of timing of catagen; • negative regulation of keratinocyte differentiation; • negative regulation of transcription regulatory region DNA binding; • embryonic limb morphogenesis; • frontal suture morphogenesis; • mammary gland epithelium development; • BMP signaling pathway involved in heart development; • enamel mineralization; • ossification; • anterior/posterior pattern specification; • bone morphogenesis; • GO:0009373 regulation of transcription, DNA-templated; • cellular response to growth factor stimulus; • activation of meiosis; • endochondral bone growth; • wound healing, spreading of epidermal cells; • BMP signaling pathway; • embryonic digit morphogenesis; • positive regulation of mesenchymal cell apoptotic process; • multicellular organism development; • embryonic hindlimb morphogenesis; • negative regulation of CREB transcription factor activity; • outflow tract morphogenesis; • bone trabecula formation; • wound healing; • regulation of apoptotic process; • chondrocyte development; • osteoblast development; • positive regulation of osteoblast differentiation; • cranial suture morphogenesis; • negative regulation of fat cell differentiation; • branching involved in mammary gland duct morphogenesis; • outflow tract septum morphogenesis; • GO:0045996 negative regulation of transcription, DNA-templated; • osteoblast differentiation; • epithelial to mesenchymal transition involved in endocardial cushion formation; • positive regulation of BMP signaling pathway; • signal transduction involved in regulation of gene expression; • cellular response to estradiol stimulus; • embryonic forelimb morphogenesis; • embryonic nail plate morphogenesis; • negative regulation of apoptotic process; • cartilage development; • stem cell differentiation; • odontogenesis; • transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • embryonic morphogenesis;
	Sources:Amigo / QuickGO
Orthologau
	4488
	n/a
	ENSG00000120149
	n/a
	P35548
	n/a
	NM_002449; NM_001363626
	n/a
	NP_002440; NP_001350555
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MSX2 yw MSX2 a elwir hefyd yn Msh homeobox 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q35.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MSX2.

FPP
MSH
PFM
CRS2
HOX8
PFM1

Llyfryddiaeth

"Prognostic Relevance and Function of MSX2 in Colorectal Cancer. ". J Diabetes Res. 2017. PMID 28286778.
"MSX2 Induces Trophoblast Invasion in Human Placenta. ". PLoS One. 2016. PMID 27088357.
"MSX2 Gene Duplication in a Patient with Eye Development Defects. ". Ophthalmic Genet. 2015. PMID 24666290.
"Boston type craniosynostosis: report of a second mutation in MSX2. ". Am J Med Genet A. 2013. PMID 23949913.
"Microduplications upstream of MSX2 are associated with a phenocopy of cleidocranial dysplasia.". J Med Genet. 2012. PMID 22717651.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MSX2 - Cronfa NCBI

[1]

[2]

MSX2

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

Content Disclaimer