MSX1

MSX1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1IG7
Dynodwyr
Cyfenwau	MSX1, ECTD3, HOX7, HYD1, STHAG1, msh homeobox 1
Dynodwyr allanol	OMIM: 142983 HomoloGene: 1836 GeneCards: MSX1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • p53 binding; • DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• nucleoplasm; • cnewyllyn cell;
Prosesau biolegol	• anterior/posterior pattern specification; • negative regulation of cell population proliferation; • negative regulation of striated muscle cell differentiation; • signal transduction involved in regulation of gene expression; • regulation of odontogenesis; • negative regulation of transcription regulatory region DNA binding; • stem cell differentiation; • positive regulation of mesenchymal cell apoptotic process; • mammary gland epithelium development; • negative regulation of apoptotic process; • activation of meiosis; • positive regulation of BMP signaling pathway; • transcription, DNA-templated; • cartilage morphogenesis; • positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; • multicellular organism development; • odontogenesis; • bone morphogenesis; • embryonic limb morphogenesis; • BMP signaling pathway; • middle ear morphogenesis; • mesenchymal cell proliferation; • embryonic forelimb morphogenesis; • negative regulation of DNA binding; • positive regulation of DNA damage response, signal transduction by p53 class mediator; • heart morphogenesis; • BMP signaling pathway involved in heart development; • GO:0000767 cell morphogenesis; • development of the heart; • forebrain development; • muscle organ development; • GO:1901227 negative regulation of transcription by RNA polymerase II; • roof of mouth development; • embryonic digit morphogenesis; • in utero embryonic development; • protein stabilization; • GO:0009373 regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • epithelial to mesenchymal transition involved in endocardial cushion formation; • transcription by RNA polymerase II; • negative regulation of cell growth; • epithelial to mesenchymal transition; • embryonic hindlimb morphogenesis; • GO:0045996 negative regulation of transcription, DNA-templated; • protein localization to nucleus; • midbrain development; • odontogenesis of dentin-containing tooth; • embryonic nail plate morphogenesis; • face morphogenesis; • pituitary gland development; • cellular response to nicotine; • cartilage development; • embryonic morphogenesis;
	Sources:Amigo / QuickGO
Orthologau
	4487
	n/a
	ENSG00000163132
	n/a
	P28360
	n/a
	NM_002448
	n/a
	NP_002439
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MSX1 yw MSX1 a elwir hefyd yn Msh homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p16.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MSX1.

HOX7
HYD1
ECTD3
STHAG1

Llyfryddiaeth

"MSX1 gene polymorphisms in Mexican patients with non-syndromic cleft lip/palate. ". Int J Pediatr Otorhinolaryngol. 2016. PMID 27729116.
"A novel MSX1 intronic mutation associated with autosomal dominant non-syndromic oligodontia in a large Chinese family pedigree. ". Clin Chim Acta. 2016. PMID 27485761.
"MSX1 mutations and associated disease phenotypes: genotype-phenotype relations. ". Eur J Hum Genet. 2016. PMID 27381090.
"Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis. ". Eur J Med Genet. 2016. PMID 27365112.
"Association of MSX1 c.*6Câ€‰>â€‰T Variant with Nonsyndromic Cleft Lip With or Without Cleft Palate in Turkish Patients.". Genet Test Mol Biomarkers. 2016. PMID 27228008.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MSX1 - Cronfa NCBI

[1]

[2]

MSX1

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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