MMP11

MMP11
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HV5
Dynodwyr
Cyfenwau	MMP11, SL-3, ST3, STMY3, matrix metallopeptidase 11
Dynodwyr allanol	OMIM: 185261 HomoloGene: 38116 GeneCards: MMP11
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • zinc ion binding • GO:0070122 peptidase activity • metalloendopeptidase activity • hydrolase activity • metallopeptidase activity • metal ion binding • serine-type endopeptidase activity Cydrannau o'r gell • Golgi lumen • extracellular region • GO:0005578 extracellular matrix • extracellular space Prosesau biolegol • collagen catabolic process • multicellular organism development • negative regulation of fat cell differentiation • extracellular matrix disassembly • proteolysis • collagen fibril organization • basement membrane organization • extracellular matrix organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4320	n/a
Ensembl	n/a	n/a
UniProt	P24347	n/a
RefSeq (mRNA)	NM_005940	n/a
RefSeq (protein)	NP_005931 NP_005931.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MMP11 yw MMP11 a elwir hefyd yn Matrix metallopeptidase 11 (Stromelysin 3), isoform CRA_b a Matrix metallopeptidase 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q11.23.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MMP11.

• ST3
• SL-3
• STMY3

• "The downregulation of miR‑125a‑5p functions as a tumor suppressor by directly targeting MMP‑11 in osteosarcoma. ". Mol Med Rep. 2016. PMID 27081863.
• "Elevated serum levels of MMP-11 correlate with poor prognosis in colon cancer patients. ". Cancer Biomark. 2016. PMID 27002762.
• "Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease. ". Turk Neurosurg. 2016. PMID 26956825.
• "Insights into the distinct roles of MMP-11 in tumor biology and future therapeutics (Review). ". Int J Oncol. 2016. PMID 26892540.
• "Matrix metalloproteinase-11 as a marker of metastasis and predictor of poor survival in urothelial carcinomas.". J Surg Oncol. 2016. PMID 26861489.