MAPK9

MAPK9
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3E7O, 3NPC
Dynodwyr
Cyfenwau	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK, mitogen-activated protein kinase 9
Dynodwyr allanol	OMIM: 602896 HomoloGene: 55685 GeneCards: MAPK9
EC number	2.7.11.24
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • MAP kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • transcription factor binding • JUN kinase activity • protein serine/threonine/tyrosine kinase activity Cydrannau o'r gell • cytosol • nucleoplasm • mitocondria • cnewyllyn cell • cytoplasm • neuron projection Prosesau biolegol • response to cadmium ion • phosphorylation • proses rythmig • positive regulation of apoptotic signaling pathway • positive regulation of podosome assembly • Fc-epsilon receptor signaling pathway • protein phosphorylation • positive regulation of macrophage derived foam cell differentiation • GO:1901313 positive regulation of gene expression • JUN phosphorylation • regulation of circadian rhythm • JNK cascade • response to mechanical stimulus • positive regulation of apoptotic process • neuron development • cellular response to organic substance • protein localization to tricellular tight junction • GO:0072353 cellular response to reactive oxygen species • cellular response to cadmium ion • GO:0035404 peptidyl-serine phosphorylation • positive regulation of protein ubiquitination • positive regulation of transcription factor catabolic process • regulation of gene expression • GO:0007243 intracellular signal transduction • regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5601	n/a
Ensembl	ENSG00000050748	n/a
UniProt	P45984	n/a
RefSeq (mRNA)	NM_001135044 NM_001308244 NM_002752 NM_139068 NM_139069 NM_139070 NM_001364607 NM_001364608 NM_001364609 NM_001364610 NM_001364611 NM_001364612 NM_001364613	n/a
RefSeq (protein)	NP_001128516 NP_001295173 NP_002743 NP_620707 NP_620708 NP_620709 NP_001351536 NP_001351537 NP_001351538 NP_001351539 NP_001351540 NP_001351541 NP_001351542	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAPK9 yw MAPK9 a elwir hefyd yn Mitogen-activated protein kinase 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q35.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAPK9.

• "Inactivation of JNK2 as carcinogenic factor in colitis-associated and sporadic colorectal carcinogenesis. ". Carcinogenesis. 2017. PMID 28383667.
• "Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes. ". Arthritis Rheumatol. 2015. PMID 25776267.
• "JNK2 is activated during ER stress and promotes cell survival. ". Cell Death Dis. 2012. PMID 23171849.
• "Molecular cloning and characterization of novel human JNK2 (MAPK9) transcript variants that show different stimulation activities on AP-1. ". BMB Rep. 2010. PMID 21110917.
• "Elevated expression of phosphorylated c-Jun NH2-terminal kinase in basal-like and "triple-negative" breast cancers.". Hum Pathol. 2010. PMID 19913278.