MAP3K5

MAP3K5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CLQ, 3VW6, 4BF2, 4BHN, 4BIB, 4BIC, 4BID, 4BIE
Dynodwyr
Cyfenwau	MAP3K5, ASK1, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5
Dynodwyr allanol	OMIM: 602448 HomoloGene: 38114 GeneCards: MAP3K5
EC number	2.7.11.25
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • protein homodimerization activity • metal ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • protein phosphatase binding • MAP kinase kinase kinase activity • ATP binding • protein kinase binding • magnesium ion binding • protein serine/threonine kinase activity • protein domain specific binding • identical protein binding Cydrannau o'r gell • cytoplasm • protein kinase complex • Reticwlwm endoplasmig • IRE1-TRAF2-ASK1 complex • cytosol • external side of plasma membrane • GO:0009327 protein-containing complex Prosesau biolegol • intrinsic apoptotic signaling pathway in response to oxidative stress • positive regulation of protein phosphorylation • phosphorylation • proses y system imiwnedd • regulation of cell death • positive regulation of neuron death • positive regulation of JNK cascade • response to endoplasmic reticulum stress • cellular response to reactive nitrogen species • MAPK cascade • protein phosphorylation • JNK cascade • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • response to ischemia • positive regulation of myoblast differentiation • positive regulation of apoptotic process • apoptotic signaling pathway • p38MAPK cascade • programmed necrotic cell death • innate immune response • GO:0022415 viral process • cellular response to hydrogen peroxide • GO:0097285 apoptotic process • cellular response to tumor necrosis factor • positive regulation of cardiac muscle cell apoptotic process • positive regulation of p38MAPK cascade • wound healing • positive regulation of JUN kinase activity • positive regulation of vascular associated smooth muscle cell proliferation • endothelial cell apoptotic process • cellular response to amino acid starvation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • stress-activated MAPK cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4217	n/a
Ensembl	ENSG00000197442	n/a
UniProt	Q99683	n/a
RefSeq (mRNA)	NM_005923	n/a
RefSeq (protein)	NP_005914	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP3K5 yw MAP3K5 a elwir hefyd yn Mitogen-activated protein kinase kinase kinase 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q23.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP3K5.

• ASK1
• MEKK5
• MAPKKK5

• "Dynamic Phosphorylation of Apoptosis Signal Regulating Kinase 1 (ASK1) in Response to Oxidative and Electrophilic Stress. ". Chem Res Toxicol. 2016. PMID 27989136.
• "MicroRNA-Mediated Down-Regulation of Apoptosis Signal-Regulating Kinase 1 (ASK1) Attenuates the Apoptosis of Human Mesenchymal Stem Cells (MSCs) Transplanted into Infarcted Heart. ". Int J Mol Sci. 2016. PMID 27775615.
• "4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells. ". Biochem Biophys Res Commun. 2016. PMID 26773495.
• "Genetic variation in the TNF/TRAF2/ASK1/p38 kinase signaling pathway as markers for postoperative pulmonary complications in lung cancer patients. ". Sci Rep. 2015. PMID 26165383.
• "[ASK1-MAP kinase signaling pathway as a therapeutic target for human diseases].". Nihon Rinsho. 2014. PMID 24912301.