LIMA1

LIMA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D8Y
Dynodwyr
Cyfenwau	LIMA1, EPLIN, SREBP3, LIM domain and actin binding 1, LDLCQ8
Dynodwyr allanol	OMIM: 608364 HomoloGene: 9484 GeneCards: LIMA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • actin filament binding • actin binding • actin monomer binding • GO:0001948, GO:0016582 protein binding • metal ion binding • cadherin binding Cydrannau o'r gell • cell junction • cleavage furrow • Cytosgerbwd • brush border • stress fiber • focal adhesion • actin cytoskeleton • cytoplasm Prosesau biolegol • negative regulation of actin filament depolymerization • ruffle organization • actin filament bundle assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51474	n/a
Ensembl	ENSG00000050405	n/a
UniProt	Q9UHB6	n/a
RefSeq (mRNA)	NM_001113546 NM_001113547 NM_001243775 NM_016357	n/a
RefSeq (protein)	NP_001107018 NP_001107019 NP_001230704 NP_057441	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIMA1 yw LIMA1 a elwir hefyd yn LIM domain and actin-binding protein 1 a LIM domain and actin binding 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.12.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LIMA1.

• EPLIN
• SREBP3

• "EPLIN-α expression in human oesophageal cancer and its impact on cellular aggressiveness and clinical outcome. ". Anticancer Res. 2012. PMID 22493360.
• "Epithelial protein lost in neoplasm (EPLIN) interacts with α-catenin and actin filaments in endothelial cells and stabilizes vascular capillary network in vitro. ". J Biol Chem. 2012. PMID 22194609.
• "Epithelial protein lost in neoplasm-α (EPLIN-α) is a potential prognostic marker for the progression of epithelial ovarian cancer. ". Int J Oncol. 2016. PMID 27035883.
• "EPLIN: a fundamental actin regulator in cancer metastasis?". Cancer Metastasis Rev. 2015. PMID 26350886.
• "Epidermal growth factor promotes protein degradation of epithelial protein lost in neoplasm (EPLIN), a putative metastasis suppressor, during epithelial-mesenchymal transition.". J Biol Chem. 2013. PMID 23188829.