LILRB1

LILRB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1G0X, 1P7Q, 1UFU, 1UGN, 1VDG, 3D2U, 4LL9, 4NO0
Dynodwyr
Cyfenwau	LILRB1, CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB, leukocyte immunoglobulin like receptor B1
Dynodwyr allanol	OMIM: 604811 HomoloGene: 88463 GeneCards: LILRB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • MHC class I receptor activity • SH2 domain binding • protein phosphatase 1 binding • HLA-A specific inhibitory MHC class I receptor activity • HLA-B specific inhibitory MHC class I receptor activity • MHC class I protein binding • amyloid-beta binding • GO:0001948, GO:0016582 protein binding • MHC class Ib receptor activity • MHC class Ib protein complex binding • MHC class Ib protein binding Cydrannau o'r gell • cytoplasm • integral component of membrane • bilen • cellbilen • extracellular region • external side of plasma membrane Prosesau biolegol • negative regulation of endocytosis • dendritic cell differentiation • negative regulation of mononuclear cell proliferation • negative regulation of interferon-gamma production • adaptive immune response • Fc receptor mediated inhibitory signaling pathway • negative regulation of osteoclast development • proses y system imiwnedd • response to virus • receptor internalization • negative regulation of cell cycle • GO:0002719 negative regulation of cytokine production involved in immune response • negative regulation of serotonin secretion • T cell proliferation involved in immune response • negative regulation of alpha-beta T cell activation • negative regulation of T cell mediated cytotoxicity • positive regulation of cytolysis • negative regulation of T cell proliferation • GO:1901313 positive regulation of gene expression • defense response to virus • negative regulation of calcium ion transport • regulation of immune response • positive regulation of apoptotic process • negative regulation of natural killer cell mediated cytotoxicity • negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • cellular response to lipopolysaccharide • immune response-inhibiting cell surface receptor signaling pathway • positive regulation of gamma-delta T cell activation involved in immune response • negative regulation of dendritic cell apoptotic process • negative regulation of dendritic cell differentiation • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of CD8-positive, alpha-beta T cell activation • positive regulation of defense response to virus by host • positive regulation of macrophage cytokine production Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10859	n/a
Ensembl	ENSG00000104972 ENSG00000276452 ENSG00000277134 ENSG00000274669 ENSG00000277807 n/a	n/a
UniProt	Q8NHL6	n/a
RefSeq (mRNA)	NM_001081637 NM_001081638 NM_001081639 NM_001278398 NM_001278399 NM_006669 NM_001388355 NM_001388356 NM_001388357 NM_001388358	n/a
RefSeq (protein)	NP_001075106 NP_001075107 NP_001075108 NP_001265327 NP_001265328 NP_006660	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LILRB1 yw LILRB1 a elwir hefyd yn Leukocyte immunoglobulin-like receptor subfamily B member 1 a Leukocyte immunoglobulin like receptor B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.42.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LILRB1.

• "Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade. ". Eur J Immunol. 2015. PMID 25726929.
• "Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue. ". Proc Natl Acad Sci U S A. 2014. PMID 24550301.
• "Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. ". Nat Immunol. 2018. PMID 29180808.
• "Multiplex bead-based immunoassay for the free soluble forms of the HLA-G receptors, ILT2 and ILT4. ". Hum Immunol. 2016. PMID 26874236.
• "Latent Cytomegalovirus Infection in Rheumatoid Arthritis and Increased Frequencies of Cytolytic LIR-1+CD8+ T Cells.". Arthritis Rheumatol. 2016. PMID 26314621.