LIG4

LIG4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1IK9, 2E2W, 3II6, 3VNN, 3W1B, 3W1G, 3W5O, 4HTO, 4HTP
Dynodwyr
Cyfenwau	LIG4, LIG4S, DNA ligase 4
Dynodwyr allanol	OMIM: 601837 HomoloGene: 1736 GeneCards: LIG4
EC number	6.5.1.1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • metal ion binding; • protein C-terminus binding; • GO:0001948, GO:0016582 protein binding; • ATP binding; • DNA ligase (ATP) activity; • ligase activity; • DNA binding; • DNA ligase activity;
Cydrannau o'r gell	• nucleoplasm; • DNA ligase IV complex; • nonhomologous end joining complex; • condensed chromosome; • cnewyllyn cell; • DNA-dependent protein kinase-DNA ligase 4 complex; • cytoplasm; • cytoplasmic ribonucleoprotein granule;
Prosesau biolegol	• nucleotide-excision repair, DNA gap filling; • double-strand break repair via classical nonhomologous end joining; • response to ionizing radiation; • DNA recombination; • lagging strand elongation; • DNA biosynthetic process; • cellular response to lithium ion; • single strand break repair; • cellular response to DNA damage stimulus; • Cellraniad; • DNA replication; • GO:1903310 positive regulation of chromosome organization; • establishment of integrated proviral latency; • cell cycle; • response to X-ray; • positive regulation of neurogenesis; • DNA ligation involved in DNA recombination; • DNA ligation; • DNA ligation involved in DNA repair; • somatic stem cell population maintenance; • GO:0051312, GO:0007083 chromosome organization; • T cell receptor V(D)J recombination; • neuron apoptotic process; • isotype switching; • T cell differentiation in thymus; • central nervous system development; • immunoglobulin V(D)J recombination; • double-strand break repair via nonhomologous end joining; • positive regulation of fibroblast proliferation; • in utero embryonic development; • cell population proliferation; • V(D)J recombination; • pro-B cell differentiation; • GO:0100026 DNA repair; • response to gamma radiation; • double-strand break repair; • GO:1904089 negative regulation of neuron apoptotic process; • cellular response to ionizing radiation;
	Sources:Amigo / QuickGO
Orthologau
	3981
	n/a
	ENSG00000174405
	n/a
	P49917
	n/a
NM_001098268; NM_002312; NM_206937; NM_001330595; NM_001352598;
	NM_001352599; NM_001352600; NM_001352601; NM_001352602; NM_001352603; NM_001352604; NM_001379095
	n/a
NP_001091738; NP_001317524; NP_002303; NP_996820; NP_001339527;
	NP_001339528; NP_001339529; NP_001339530; NP_001339531; NP_001339532; NP_001339533; NP_001366024
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIG4 yw LIG4 a elwir hefyd yn DNA ligase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q33.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LIG4.

LIG4S

Llyfryddiaeth

"LIG4 mediates Wnt signalling-induced radioresistance. ". Nat Commun. 2016. PMID 27009971.
"Molecular and immunological characterization of DNA ligase IV deficiency. ". Clin Immunol. 2016. PMID 26762768.
"DNA ligase4 as a prognostic marker in nasopharyngeal cancer patients treated with radiotherapy. ". Asian Pac J Cancer Prev. 2014. PMID 25605214.
"Relevance of LIG4 gene polymorphisms with cancer susceptibility: evidence from a meta-analysis. ". Sci Rep. 2014. PMID 25314918.
"DNA Ligase IV regulates XRCC4 nuclear localization.". DNA Repair (Amst). 2014. PMID 24984242.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LIG4 - Cronfa NCBI

[1]

[2]

LIG4

Cyfystyron

Llyfryddiaeth

Cyfeiriadau

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